A new cytogenetic abnormality, t(2;7)(q33;q36), in acute promyelocytic leukemia

被引：2
|
作者：
Owatari, Satsuki
Uozumi, Kimliharu
Haraguchi, Kouichi
Ohno, Nobuhito
Tokunaga, Masahito
Tokunaga, Mayumi
Suzuki, Shinsuke
Hanada, Shuichi
Arima, Naomichi
机构：
[1] Kagoshima Univ, Dept Hematol & Immunol, Kagoshima 8908520, Japan
[2] Natl Hosp Org, Kagoshima Med Ctr, Dept Internal Med, Kagoshima 8920853, Japan
来源：
CANCER GENETICS AND CYTOGENETICS | 2007年 / 173卷 / 01期
关键词：
D O I：
10.1016/j.cancergencyto.2006.08.013
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We report the case of a patient with acute promyelocytic leukemia (APL) carrying a novel chromosomal abnormality, t(2;7)(q33;q36). The 54-year-old woman was morphologically diagnosed with APL through bone marrow aspiration. The proportion of blast cells in bone marrow was 78%, including cells displaying Auer rods and faggot cells. Chromosomal analysis revealed the karyotype 46,XX,t(2;7)(q33;q36)[17]/46,XX[3]. The t(15;17) was not detected with conventional cytogenetic analysis. However, reverse transcriptase-polymerase chain reaction revealed the presence of a PML/RARA fusion gene. Cells displaying t(2;7)(q33;q36) disappeared after complete remission was achieved, using induction chemotherapy. Although several additional chromosomal abnormalities have been reported, this t(2;7)(q33;q36) without the classic t(15; 17) represents a novel chromosomal abnormality associated with APL. (c) 2007 Elsevier Inc. All rights reserved.
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收藏
页码：71 / 74
页数：4
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