A new cytogenetic abnormality, t(2;7)(q33;q36), in acute promyelocytic leukemia

被引：2

作者：

Owatari, Satsuki

Uozumi, Kimliharu

Haraguchi, Kouichi

Ohno, Nobuhito

Tokunaga, Masahito

Tokunaga, Mayumi

Suzuki, Shinsuke

Hanada, Shuichi

Arima, Naomichi

机构：

[1] Kagoshima Univ, Dept Hematol & Immunol, Kagoshima 8908520, Japan

[2] Natl Hosp Org, Kagoshima Med Ctr, Dept Internal Med, Kagoshima 8920853, Japan

来源：

CANCER GENETICS AND CYTOGENETICS | 2007年 / 173卷 / 01期

关键词：

D O I：

10.1016/j.cancergencyto.2006.08.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report the case of a patient with acute promyelocytic leukemia (APL) carrying a novel chromosomal abnormality, t(2;7)(q33;q36). The 54-year-old woman was morphologically diagnosed with APL through bone marrow aspiration. The proportion of blast cells in bone marrow was 78%, including cells displaying Auer rods and faggot cells. Chromosomal analysis revealed the karyotype 46,XX,t(2;7)(q33;q36)[17]/46,XX[3]. The t(15;17) was not detected with conventional cytogenetic analysis. However, reverse transcriptase-polymerase chain reaction revealed the presence of a PML/RARA fusion gene. Cells displaying t(2;7)(q33;q36) disappeared after complete remission was achieved, using induction chemotherapy. Although several additional chromosomal abnormalities have been reported, this t(2;7)(q33;q36) without the classic t(15; 17) represents a novel chromosomal abnormality associated with APL. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：71 / 74

页数：4

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