Total Synthesis of Bengazole A

被引：41

作者：

Chandrasekhar, Srivari ^{[1
]}

Sudhakar, Ambadi ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Organ Div 1, Hyderabad 500007, Andhra Pradesh, India

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 02期

关键词：

NATURAL-PRODUCTS; DRUG DISCOVERY; MARINE SPONGE; OXAZOLES; CORE;

D O I：

10.1021/ol9024138

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The divergent and enantioselective total synthesis of the powerful antifungal marine natural product bengazole A has been achieved.

引用

页码：236 / 238

页数：3

共 26 条

[1] UNUSUAL ANTHELMINTIC OXAZOLES FROM A MARINE SPONGE [J].

ADAMCZESKI, M ;

QUINOA, E ;

CREWS, P .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (05) :1598-1602

[2] SCREENING OF MARINE-INVERTEBRATES FOR THE PRESENCE OF ERGOSTEROL-SENSITIVE ANTIFUNGAL COMPOUNDS [J].

ANTONIO, J ;

MOLINSKI, TF .

JOURNAL OF NATURAL PRODUCTS, 1993, 56 (01) :54-61

[3] Marine natural product libraries for high-throughput screening and rapid drug discovery [J].

Bugni, Tim S. ;

Richards, Burt ;

Bhoite, Leen ;

Cimbora, Daniel ;

Harper, Mary Kay ;

Ireland, Chris M. .

JOURNAL OF NATURAL PRODUCTS, 2008, 71 (06) :1095-1098

[4] Total synthesis of potent antifungal marine bisoxazole natural products bengazoles A and B [J].

Bull, James A. ;

Balskus, Emily P. ;

Horan, Richard A. J. ;

Langner, Martin ;

Ley, Steven V. .

CHEMISTRY-A EUROPEAN JOURNAL, 2007, 13 (19) :5515-5538

[5] Stereocontrolled total synthesis of bengazole A: A marine bisoxazole natural product displaying potent antifungal properties [J].

Bull, James A. ;

Balskus, Emily P. ;

Horan, Richard A. J. ;

Langner, Martin ;

Ley, Steven V. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (40) :6714-6718

[6] The role of natural product chemistry in drug discovery [J].

Butler, MS .

JOURNAL OF NATURAL PRODUCTS, 2004, 67 (12) :2141-2153

[7] Spirastrellolide B:: The synthesis of southern (C9-C25) region [J].

Chandrasekhar, Srivari ;

Rambabu, Chegondi ;

Reddy, Annareddy Syamprasad .

ORGANIC LETTERS, 2008, 10 (19) :4355-4357

[8] Stereoselective formal total synthesis of the cyclodepsipeptide (-)-spongidepsin [J].

Chandrasekhar, Srivari ;

Yaragorla, Srinivasa Rao ;

Sreelakshmi, Lella .

TETRAHEDRON LETTERS, 2007, 48 (41) :7339-7342

[9] 1,3-SYN DIASTEREOSELECTIVE REDUCTION OF BETA-HYDROXYKETONES UTILIZING ALKOXYDIALKYLBORANES [J].

CHEN, KM ;

HARDTMANN, GE ;

PRASAD, K ;

REPIC, O ;

SHAPIRO, MJ .

TETRAHEDRON LETTERS, 1987, 28 (02) :155-158

[10]

Chittari P, 1998, SYNLETT, P1022

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