Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for UGT1A1 and Atazanavir Prescribing

被引：174
作者：
Gammal, R. S. [1 ]
Court, M. H. [2 ]
Haidar, C. E. [1 ]
Iwuchukwu, O. F. [3 ,4 ]
Gaur, A. H. [5 ]
Alvarellos, M. [6 ]
Guillemette, C. [7 ]
Lennox, J. L. [8 ]
Whirl-Carrillo, M. [6 ]
Brummel, S. S. [9 ]
Ratain, M. J. [10 ]
Klein, T. E. [6 ]
Schackman, B. R. [11 ]
Caudle, K. E. [1 ]
Haas, D. W. [12 ,13 ,14 ,15 ]
机构：
[1] St Jude Childrens Res Hosp, Dept Pharmaceut Sci, 332 N Lauderdale St, Memphis, TN 38105 USA
[2] Washington State Univ, Coll Vet Med, Dept Vet Clin Sci, Individualized Med Program, Pullman, WA 99164 USA
[3] Fairleigh Dickinson Univ, Sch Pharm, Div Pharmaceut Sci, Florham Pk, NJ USA
[4] Vanderbilt Univ, Med Ctr, Dept Med, Div Clin Pharmacol, Nashville, TN USA
[5] St Jude Childrens Res Hosp, Dept Infect Dis, 332 N Lauderdale St, Memphis, TN 38105 USA
[6] Stanford Univ, Dept Genet, Stanford, CA 94305 USA
[7] Univ Laval, CHU Quebec, Res Ctr, Quebec City, PQ, Canada
[8] Emory Univ, Sch Med, Div Infect Dis, Atlanta, GA 30322 USA
[9] Harvard Univ, TH Chan Sch Publ Hlth, Ctr Biostat AIDS Res, Boston, MA 02115 USA
[10] Univ Chicago, Ctr Comprehens Canc, Ctr Personalized Therapeut, Chicago, IL 60637 USA
[11] Weill Cornell Med Coll, Dept Healthcare Policy & Res, New York, NY USA
[12] Vanderbilt Univ, Sch Med, Dept Med, Nashville, TN 37212 USA
[13] Vanderbilt Univ, Sch Med, Dept Pharmacol, Nashville, TN 37212 USA
[14] Vanderbilt Univ, Sch Med, Dept Pathol, Nashville, TN 37212 USA
[15] Vanderbilt Univ, Sch Med, Dept Microbiol & Immunol, Nashville, TN 37212 USA
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS | 2016年 / 99卷 / 04期
基金：
美国国家卫生研究院;
关键词：
GENOME-WIDE ASSOCIATION; SERUM BILIRUBIN LEVELS; RITONAVIR; EFFICACY; POLYMORPHISMS; PROMOTER; THERAPY; MARKER; SAFETY; UDP-GLUCURONOSYLTRANSFERASE-1;
D O I：
10.1002/cpt.269
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The antiretroviral protease inhibitor atazanavir inhibits hepatic uridine diphosphate glucuronosyltransferase (UGT) 1A1, thereby preventing the glucuronidation and elimination of bilirubin. Resultant indirect hyperbilirubinemia with jaundice can cause premature discontinuation of atazanavir. Risk for bilirubin-related discontinuation is highest among individuals who carry two UGT1A1 decreased function alleles (UGT1A1*28 or *37). We summarize published literature that supports this association and provide recommendations for atazanavir prescribing when UGT1A1 genotype is known (updates at www.pharmgkb.org).
引用
收藏
页码：363 / 369
页数：7
相关论文
共 41 条
[1]   PharmGKB summary: very important pharmacogene information for UGT1A1 [J].
Barbarino, Julia M. ;
Haidar, Cyrine E. ;
Klein, Teri E. ;
Altman, Russ B. .
PHARMACOGENETICS AND GENOMICS, 2014, 24 (03) :177-183
[2]   Assessment of UGT Polymorphisms and Neonatal Jaundice [J].
Bartlett, Mark G. ;
Gourley, Glenn R. .
SEMINARS IN PERINATOLOGY, 2011, 35 (03) :127-133
[3]  
BOSMA PJ, 1994, J BIOL CHEM, V269, P17960
[4]   THE GENETIC-BASIS OF THE REDUCED EXPRESSION OF BILIRUBIN UDP-GLUCURONOSYLTRANSFERASE-1 IN GILBERTS-SYNDROME [J].
BOSMA, PJ ;
CHOWDHURY, JR ;
BAKKER, C ;
GANTLA, S ;
DEBOER, A ;
OOSTRA, BA ;
LINDHOUT, D ;
TYTGAT, GNJ ;
JANSEN, PLM ;
ELFERINK, RPJO ;
CHOWDHURY, NR .
NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (18) :1171-1175
[5]   UGT1A1 is a major locus influencing bilirubin levels in African Americans [J].
Chen, Guanjie ;
Ramos, Edward ;
Adeyemo, Adebowale ;
Shriner, Daniel ;
Zhou, Jie ;
Doumatey, Ayo P. ;
Huang, Hanxia ;
Erdos, Michael R. ;
Gerry, Norman P. ;
Herbert, Alan ;
Bentley, Amy R. ;
Xu, Huichun ;
Charles, Bashira A. ;
Christman, Michael F. ;
Rotimi, Charles N. .
EUROPEAN JOURNAL OF HUMAN GENETICS, 2012, 20 (04) :463-468
[6]   UGT1A1 sequence variants associated with risk of adult hyperbilirubinemia: A quantitative analysis [J].
Chen, Zhiwei ;
Su, Dazhi ;
Ai, Luoyan ;
Jiang, Xiaoke ;
Wu, Changwei ;
Xu, Qingqing ;
Wang, Xiaohan ;
Fan, Zhuping .
GENE, 2014, 552 (01) :32-38
[7]   Quantitative distribution of mRNAs encoding the 19 human UDP-glucuronosyltransferase enzymes in 26 adult and 3 fetal tissues [J].
Court, Michael H. ;
Zhang, Xiuling ;
Ding, Xinxin ;
Yee, Karen K. ;
Hesse, Leah M. ;
Finel, Moshe .
XENOBIOTICA, 2012, 42 (03) :266-277
[8]   Atazanavir Plus Ritonavir or Efavirenz as Part of a 3-Drug Regimen for Initial Treatment of HIV-1 [J].
Daar, Eric S. ;
Tierney, Camlin ;
Fischl, Margaret A. ;
Sax, Paul E. ;
Mollan, Katie ;
Budhathoki, Chakra ;
Godfrey, Catherine ;
Jahed, Nasreen C. ;
Myers, Laurie ;
Katzenstein, David ;
Farajallah, Awny ;
Rooney, James F. ;
Pappa, Keith A. ;
Woodward, William C. ;
Patterson, Kristine ;
Bolivar, Hector ;
Benson, Constance A. ;
Collier, Ann C. .
ANNALS OF INTERNAL MEDICINE, 2011, 154 (07) :445-456
[9]   A Genome-Wide Association Study for Serum Bilirubin Levels and Gene-Environment Interaction in a Chinese Population [J].
Dai, Xiayun ;
Wu, Chen ;
He, Yunfeng ;
Gui, Lixuan ;
Zhou, Li ;
Guo, Huan ;
Yuan, Jing ;
Yang, Binyao ;
Li, Jun ;
Deng, Qifei ;
Huang, Suli ;
Guan, Lei ;
Hu, Die ;
Zhu, Jiang ;
Min, Xinwen ;
Lang, Mingjian ;
Li, Dongfeng ;
Yang, Handong ;
Hu, Frank B. ;
Lin, Dongxin ;
Wu, Tangchun ;
He, Meian .
GENETIC EPIDEMIOLOGY, 2013, 37 (03) :293-300
[10]  
Eley T, 2013, AIDS RES HUM RETROV, V29, P1287, DOI [10.1089/aid.2013.0002, 10.1089/AID.2013.0002]
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