Chronic Fragmentation of the Daily Sleep-Wake Rhythm Increases Amyloid-beta Levels and Neuroinflammation in the 3xTg-AD Mouse Model of Alzheimer's Disease

被引：25
作者：
Kohler, K. [3 ,4 ]
Salisbury, F. [2 ]
Wessel, C. [4 ]
Wang, J. [5 ]
Sunderam, S. [5 ]
Duncan, M. J. [1 ]
Guerriero, L. E. [2 ]
Beechem, L. E.
Gillis, B. D. [3 ]
Bachstetter, A. D. [1 ,4 ,6 ]
O'Hara, B. F. [2 ]
Murphy, M. P. [3 ,4 ]
机构：
[1] Univ Kentucky Coll Med, Dept Neurosci, Lexington, KY 40536 USA
[2] Univ Kentucky, Dept Biol, Lexington, KY 40506 USA
[3] Univ Kentucky Coll Med, Dept Mol & Cellular Biochem, Lexington, KY 40536 USA
[4] Univ Kentucky Coll Med, Sanders Brown Ctr Aging, Alzheimers Dis Ctr, Lexington, KY 40536 USA
[5] Univ Kentucky, Dept Biomed Engn, Lexington, KY 40506 USA
[6] Univ Kentucky, Spinal Cord & Brain Injury Res Ctr, Lexington, KY 40536 USA
来源：
NEUROSCIENCE | 2022年 / 481卷
基金：
美国国家卫生研究院;
关键词：
sleep; Alzheimers disease; amyloid-beta; neuroinflammation; 3xTg-AD; hippocampus; MILD COGNITIVE IMPAIRMENT; A-BETA; CIRCADIAN-RHYTHMS; MEMORY; DISTURBANCES; DISRUPTION; DEPOSITION; DISORDERS; DEMENTIA;
D O I：
10.1016/j.neuroscience.2021.11.042
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Fragmentation of the daily sleep-wake rhythm with increased nighttime awakenings and more daytimenaps is correlated with the risk of development of Alzheimer's disease (AD). To explore whether a causal relation-ship underlies this correlation, the present study tested the hypothesis that chronic fragmentation of the dailysleep-wake rhythm stimulates brain amyloid-beta (A beta) levels and neuroinflammation in the 3xTg-AD mouse modelof AD. Female 3xTg-AD mice were allowed to sleep undisturbed or were subjected to chronic sleep fragmentationconsisting of four daily sessions of enforced wakefulness (one hour each) evenly distributed during the lightphase, five days a week for four weeks. Piezoelectric sleep recording revealed that sleep fragmentation alteredthe daily sleep-wake rhythm to resemble the pattern observed in AD. Levels of amyloid-beta (A beta(40)and A beta(42)) deter-mined by ELISA were higher in hippocampal tissue collected from sleep-fragmented mice than from undisturbedcontrols. In contrast, hippocampal levels of tau and phospho-tau differed minimally between sleep fragmentedand undisturbed control mice. Sleep fragmentation also stimulated neuroinflammation as shown by increasedexpression of markers of microglial activation and proinflammatory cytokines measured by q-RT-PCR analysisof hippocampal samples. No significant effects of sleep fragmentation on A beta, tau, or neuroinflammation wereobserved in the cerebral cortex. These studies support the concept that improving sleep consolidation in individ-uals at risk for AD may be beneficial for slowing the onset or progression of this devastating neurodegenerative disease.(C) 2021 IBRO. Published by Elsevier Ltd. All rights reserved
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收藏
页码：111 / 122
页数：12
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