DNA methylation in chronic obstructive pulmonary disease

被引：16

作者：

Huo, Xinxin ^{[1
]}

Jin, SiHui ^{[1
]}

Wang, Yige ^{[1
]}

Li Ma ^{[1
]}

机构：

[1] Lanzhou Univ, Sch Publ Hlth, Lanzhou, Peoples R China

来源：

EPIGENOMICS | 2021年 / 13卷 / 14期

关键词：

chronic obstructive pulmonary disease; DNA methylation; DNA methyltransferase; prevention and treatment of COPD; GENE-EXPRESSION; PROMOTER METHYLATION; ACUTE EXACERBATION; EPITHELIAL-CELLS; LUNG-CANCER; COPD; EXPOSURE; SMOKING; MARKS; METHYLTRANSFERASES;

D O I：

10.2217/epi-2021-0111

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Chronic obstructive pulmonary disease (COPD), a complex disease with polygenetic tendency, is one of the most important health problems in the world. Recently, in the study of the pathogenesis of the COPD, epigenetic changes caused by environmental factors, such as DNA methylation, started to attract more attention than genetic factors. In this review, we discuss the main features of DNA methylation, such as DNA methyltransferases and the methylation sites that modulate the DNA methylation level, and their roles in COPD progression. Finally, to promote new ideas for the prevention and treatment of COPD, we focus on the potential of DNA methylation as a COPD therapeutic target.

引用

页码：1145 / 1155

页数：11

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