Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults

被引:32
作者
Chen, Sijia [1 ,2 ]
Pawelec, Graham [3 ,4 ]
Trompet, Stella [1 ]
Goldeck, David [3 ,5 ]
Mortensen, Laust H. [6 ]
Slagboom, P. Eline [7 ]
Christensen, Kaare [8 ]
Gussekloo, Jacobijn [1 ,9 ]
Kearney, Patricia [10 ]
Buckley, Brendan M. [11 ]
Ford, Ian [12 ]
Jukema, J. Wouter [13 ]
Westendorp, Rudi G. J. [1 ,14 ,15 ]
Maier, Andrea B. [16 ,17 ]
机构
[1] Leiden Univ, Med Ctr, Dept Gerontol & Geriatr, Leiden, Netherlands
[2] Acad Med Ctr, Dept Expt Immunol, Amsterdam, Netherlands
[3] Univ Tubingen, Dept Immunol, Tubingen, Germany
[4] Hlth Sci North Res Inst, Sudbury, ON, Canada
[5] Fairfax Ctr, Kidlington, England
[6] Stat Denmark, Methods & Anal, Copenhagen, Denmark
[7] Leiden Univ, Med Ctr, Sect Mol Epidemiol, Leiden, Netherlands
[8] Univ Southern Denmark, Danish Aging Res Ctr, Odense, Denmark
[9] Leiden Univ, Med Ctr, Dept Publ Hlth & Primary Care, Leiden, Netherlands
[10] Univ Coll Cork, Dept Epidemiol & Publ Hlth, Cork, Ireland
[11] Univ Coll Cork, Dept Pharmacol & Therapeut, Cork, Ireland
[12] Univ Glasgow, Robertson Ctr Biostat, Glasgow, Lanark, Scotland
[13] Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands
[14] Leyden Acad Vital & Ageing, Leiden, Netherlands
[15] Univ Copenhagen, Dept Publ Hlth, Copenhagen, Denmark
[16] Univ Melbourne, Royal Melbourne Hosp, Dept Med & Aged Care, AgeMelbourne, Melbourne, Vic, Australia
[17] Vrije Univ, Dept Human Movement Sci, Amsterdam Movement Sci, AgeAmsterdam, Van der Boechorststr 9, NL-1081 HV Amsterdam, Netherlands
基金
美国国家卫生研究院;
关键词
Herpesviridae; cytomegalovirus; seroepidemiologic studies; immunoglobulin G; mortality; cardiovascular; aged; C-REACTIVE PROTEIN; G ANTIBODY-LEVELS; CMV INFECTION; HEART-DISEASE; RISK-FACTORS; SEROPOSITIVITY; INFLAMMATION; SURVIVAL; PRAVASTATIN; FRAILTY;
D O I
10.1093/infdis/jiaa480
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background. Whether latent cytomegalovirus (CMV) infection in older adults has any substantial health consequences is unclear. Here, we sought associations between CMV-seropositivity and IgG titer with all-cause and cardiovascular mortality in 5 longitudinal cohorts. Methods. Leiden Longevity Study, Prospective Study of Pravastatin in the Elderly at Risk, Longitudinal Study of Aging Danish Twins, and Leiden 85-plus Study were assessed at median (2.8-11.4 years) follow-up . Cox regression and random effects meta-analysis were used to estimate mortality risk dependent on CMV serostatus and/or IgG antibody titer, in quartiles after adjusting for confounders. Results. CMV-seropositivity was seen in 47%-79% of 10 122 white community-dwelling adults aged 59-93 years. Of these, 3519 had died on follow-up (579 from cardiovascular disease). CMV seropositivity was not associated with all-cause (hazard ratio [HR], 1.05; 95% confidence interval [CI], .97-1.14) or cardiovascular mortality (HR, 0.97; 95% CI, .83-1.13). Subjects in the highest CMV IgG quartile group had increased all-cause mortality relative to CMV-seronegatives (HR, 1.16; 95% CI, 1.04-1.29) but this association lost significance after adjustment for confounders (HR, 1.13; 95% CI, .99-1.29). The lack of increased mortality risk was confirmed in subanalyses. Conclusions. CMV infection is not associated with all-cause or cardiovascular mortality in white community-dwelling older adults.
引用
收藏
页码:238 / 246
页数:9
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