Differential expression of the TRAIL/TRAIL-receptor system in patients with inflammatory bowel disease

被引：27

作者：

Brost, Sylvia ^{[1
]}

Koschny, Ronald ^{[1
]}

Sykora, Jaromir ^{[1
,2
]}

Stremmel, Wolfgang ^{[1
]}

Lasitschka, Felix ^{[3
]}

Walczak, Henning ^{[4
]}

Ganten, Tom M. ^{[1
]}

机构：

[1] Univ Heidelberg Hosp, Dept Gastroenterol, D-69120 Heidelberg, Germany

[2] German Canc Res Ctr, Dept Tumor Immunol, Heidelberg, Germany

[3] Univ Heidelberg Hosp, Inst Pathol, D-69120 Heidelberg, Germany

[4] Univ London Imperial Coll Sci Technol & Med, Div Med, London, England

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2010年 / 206卷 / 01期

关键词：

TRAIL; Apoptosis; Ulcerative colitis; Crohn's disease; Appendicitis; APOPTOSIS-INDUCING LIGAND; TRAIL-INDUCED APOPTOSIS; PROPRIA T-CELLS; ULCERATIVE-COLITIS; PLASMA-CELLS; DECOY RECEPTORS; CARCINOMA CELLS; CROHNS-DISEASE; DEATH DOMAIN; IN-VIVO;

D O I：

10.1016/j.prp.2009.09.005

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

TNF-related apoptosis inducing-ligand (TRAIL) is a potent inducer of apoptosis and plays an important role in immune regulation. To explore the role of TRAIL in inflammatory bowel disease (IBD), we examined the expression of the TRAIL/TRAIL-receptor system in colonic resections from patients with ulcerative colitis and Crohn's disease in comparison to normal colon and appendicitis. TRAIL and TRAIL-receptor (TRAIL-R) expression was assessed in resections of normal colon, colon of IBD patients, and appendicitis by immunohistochemistry. TRAIL was downregulated in enterocytes of patients with IBD, but was upregulated in mononuclear cells in areas of active mucosal inflammation. For TRAIL-R1, we detected a strong downregulation in the surface epithelium in IBD but not in appendicitis. TRAIL-R2 and TRAIL-R4 were strongly downregulated in the surface epithelium in any kind of mucosal inflammation. TRAIL and TRAIL-R1 are downregulated in enterocytes, and TRAIL is upregulated in mononuclear cells only in IBD but not in normal colon or appendicitis. This may point to a pathophysiologic role of the TRAIL system in inflammatory bowel disease. (C) 2009 Elsevier GmbH. All rights reserved.

引用

页码：43 / 50

页数：8

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