Maintaining Integrity Under Stress: Envelope Stress Response Regulation of Pathogenesis in Gram-Negative Bacteria

被引：102

作者：

Hews, Claire L. ^{[1
]}

Cho, Timothy ^{[2
]}

Rowley, Gary ^{[1
]}

Raivio, Tracy L. ^{[2
]}

机构：

[1] Univ East Anglia, Sch Biol Sci, Norwich, Norfolk, England

[2] Univ Alberta, Dept Biol Sci, Edmonton, AB, Canada

来源：

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2019年 / 9卷

基金：

英国生物技术与生命科学研究理事会; 加拿大健康研究院; 加拿大自然科学与工程研究理事会;

关键词：

Gram-negative bacteria; envelope stress; pathogenesis; sigmaE response; Cpx response; III SECRETION SYSTEM; ENTERICA SEROVAR TYPHIMURIUM; ENTEROPATHOGENIC ESCHERICHIA-COLI; ALTERNATIVE SIGMA-FACTOR; OUTER-MEMBRANE LIPOPROTEIN; VIRULENCE GENE-EXPRESSION; CPX SIGNAL-TRANSDUCTION; SMALL NONCODING RNAS; PEPTIDOGLYCAN CROSS-LINKING; BARREL ASSEMBLY MACHINE;

D O I：

10.3389/fcimb.2019.00313

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Gram-negative bacterial envelope is an essential interface between the intracellular and harsh extracellular environment. Envelope stress responses (ESRs) are crucial to the maintenance of this barrier and function to detect and respond to perturbations in the envelope, caused by environmental stresses. Pathogenic bacteria are exposed to an array of challenging and stressful conditions during their lifecycle and, in particular, during infection of a host. As such, maintenance of envelope homeostasis is essential to their ability to successfully cause infection. This review will discuss our current understanding of the sigma(E)- and Cpx-regulated ESRs, with a specific focus on their role in the virulence of a number of model pathogens.

引用

页数：25

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