One-pot multicomponent synthesis and anti-microbial evaluation of 2′-(indol-3-yl)-2-oxospiro(indoline-3,4′-pyran) derivatives

被引：119
作者：
Nandakumar, A. [1 ]
Thirumurugan, Prakasam [1 ]
Perumal, Paramasivan T. [1 ]
Vembu, P. [1 ]
Ponnuswamy, M. N. [2 ]
Ramesh, P. [2 ]
机构：
[1] Cent Leather Res Inst, Div Organ Chem, Madras 600020, Tamil Nadu, India
[2] Univ Madras, Ctr Adv Study Crystallog & Biophys, Madras 600025, Tamil Nadu, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 14期
关键词：
Spiroxindoles; 3-Cyanoacetyl indole; Anti-microbial activity; Pyran ring; Isatin; BIOLOGICAL EVALUATION; EFFICIENT SYNTHESIS; INDOLE ALKALOIDS; FACILE; HETEROCYCLES; ROUTE;
D O I：
10.1016/j.bmcl.2010.05.025
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A simple and efficient method for the one-pot three-component synthesis of new spirooxindoles in room temperature is described. The newly synthesized spirooxindoles were screened for anti-microbial activity and the results are good on comparison with of standard antibacterial compounds. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4252 / 4258
页数：7
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