One-pot multicomponent synthesis and anti-microbial evaluation of 2′-(indol-3-yl)-2-oxospiro(indoline-3,4′-pyran) derivatives

被引：119

作者：

Nandakumar, A. ^{[1
]}

Thirumurugan, Prakasam ^{[1
]}

Perumal, Paramasivan T. ^{[1
]}

Vembu, P. ^{[1
]}

Ponnuswamy, M. N. ^{[2
]}

Ramesh, P. ^{[2
]}

机构：

[1] Cent Leather Res Inst, Div Organ Chem, Madras 600020, Tamil Nadu, India

[2] Univ Madras, Ctr Adv Study Crystallog & Biophys, Madras 600025, Tamil Nadu, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 14期

关键词：

Spiroxindoles; 3-Cyanoacetyl indole; Anti-microbial activity; Pyran ring; Isatin; BIOLOGICAL EVALUATION; EFFICIENT SYNTHESIS; INDOLE ALKALOIDS; FACILE; HETEROCYCLES; ROUTE;

D O I：

10.1016/j.bmcl.2010.05.025

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A simple and efficient method for the one-pot three-component synthesis of new spirooxindoles in room temperature is described. The newly synthesized spirooxindoles were screened for anti-microbial activity and the results are good on comparison with of standard antibacterial compounds. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：4252 / 4258

页数：7

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