Antibody-mediated neutralization of SARS-CoV-2

被引：104

作者：

Gruell, Henning ^{[1
,2
]}

Vanshylla, Kanika ^{[1
,2
]}

Weber, Timm ^{[1
,2
]}

Barnes, Christopher O. ^{[3
,4
]}

Kreer, Christoph ^{[1
,2
]}

Klein, Florian ^{[1
,2
,5
,6
]}

机构：

[1] Univ Cologne, Fac Med, Inst Virol, Lab Expt Immunol, D-50931 Cologne, Germany

[2] Univ Cologne, Univ Hosp Cologne, D-50931 Cologne, Germany

[3] Stanford Univ, Dept Biol, Stanford, CA 94305 USA

[4] Chan Zuckerberg Biohub, San Francisco, CA 94158 USA

[5] German Ctr Infect Res DZIF, Partner Site Bonn Cologne, D-50931 Cologne, Germany

[6] Univ Cologne, Ctr Mol Med Cologne CMMC, D-50931 Cologne, Germany

来源：

IMMUNITY | 2022年 / 55卷 / 06期

关键词：

MESSENGER-RNA VACCINATION; RECEPTOR-BINDING DOMAIN; B-CELL MEMORY; BREAKTHROUGH INFECTIONS; HUMORAL IMMUNITY; SPIKE PROTEIN; COVID-19; POTENT; MATURATION; PROTECTION;

D O I：

10.1016/j.immuni.2022.05.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neutralizing antibodies can block infection, clear pathogens, and are essential to provide long-term immunity. Since the onset of the pandemic, SARS-CoV-2 neutralizing antibodies have been comprehensively investigated and critical information on their development, function, and potential use to prevent and treat COVID-19 have been revealed. With the emergence of SARS-CoV-2 immune escape variants, humoral immunity is being challenged, and a detailed understanding of neutralizing antibodies is essential to guide vaccine design strategies as well as antibody-mediated therapies. In this review, we summarize some of the key findings on SARS-CoV-2 neutralizing antibodies, with a focus on their clinical application.

引用

页码：925 / 944

页数：20

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