The role of autophagy in steroid necrosis of the femoral head: a comprehensive research review

被引：80

作者：

Luo, Pan ^{[1
]}

Gao, Fuqiang ^{[1
,2
,3
]}

Han, Jun ^{[3
]}

Sun, Wei ^{[1
,2
,3
]}

Li, Zirong ^{[2
]}

机构：

[1] Peking Union Med Coll, China Japan Friendship Inst Clin Med, Dept Orthoped Surg, Beijing 100029, Peoples R China

[2] Peking Union Med Coll, Beijing Key Lab Arthrit & Rheumat Dis, China Japan Friendship Hosp,Natl Hlth & Family Pl, Dept Orthoped Surg,Ctr Osteonecrosis & Joint Pres, Beijing 100029, Peoples R China

[3] Peking Univ, Dept Orthoped Surg, China Japan Friendship Sch Clin Med, Beijing 100029, Peoples R China

来源：

INTERNATIONAL ORTHOPAEDICS | 2018年 / 42卷 / 07期

基金：

中国国家自然科学基金; 北京市自然科学基金;

关键词：

Osteonecrosis; Femoral head; Autophagy; PROGRAMMED CELL-DEATH; ENDOPLASMIC-RETICULUM; INDUCED OSTEONECROSIS; APOPTOSIS; BONE; GLUCOCORTICOIDS; INHIBITION; OSTEOCYTES; OSTEOBLASTS; PATHWAY;

D O I：

10.1007/s00264-018-3994-8

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Steroid-induced osteonecrosis of the femoral head (ONFH) has the incidence of 9-40% in patients receiving long-term treatment and is mainly involved in the middle and young people. It is mostly bilateral, with a wide range of necrosis and high disability rate, which brings disaster for patients and families. The experimental study shows that autophagy participates in the pathological process of steroid ONFH and is closely related to apoptosis, and the interaction between autophagy and bone cells is related to the dose of hormones. Moreover, autophagy also affects the interaction between osteoblasts and osteoclasts in ONFH. In the present review, we have discussed the role of autophagy in the pathological process of the steroid-induced ONFH.

引用

页码：1747 / 1753

页数：7

共 56 条

[21] Avascular necrosis of the femoral head:: Vascular hypotheses [J].