Maximum likelihood estimation and EM algorithm of Copas-like selection model for publication bias correction

被引:12
|
作者
Ning, Jing [1 ]
Chen, Yong [2 ]
Piao, Jin [3 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Dept Biostat, Houston, TX 77030 USA
[2] Univ Penn, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA
[3] Univ Texas Sch Publ Hlth, Dept Biostat, Houston, TX 77030 USA
基金
美国国家卫生研究院;
关键词
Copas Model; EM algorithm; Meta-analysis; Publication Bias; SYSTEMATIC REVIEWS; FILL METHOD; METAANALYSIS; TRIM;
D O I
10.1093/biostatistics/kxx004
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Publication bias occurs when the published research results are systematically unrepresentative of the population of studies that have been conducted, and is a potential threat to meaningful meta-analysis. The Copas selection model provides a flexible framework for correcting estimates and offers considerable insight into the publication bias. However, maximizing the observed likelihood under the Copas selection model is challenging because the observed data contain very little information on the latent variable. In this article, we study a Copas-like selection model and propose an expectation-maximization (EM) algorithm for estimation based on the full likelihood. Empirical simulation studies show that the EM algorithm and its associated inferential procedure performs well and avoids the non-convergence problem when maximizing the observed likelihood.
引用
收藏
页码:495 / 504
页数:10
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