Synthesis, Crystal Structure, DNA Binding, Antibacterial, and Cytotoxic Activities of Two Chiral Copper(II) Complexes

被引：25

作者：

Fei, Bao-Li ^{[1
,2
]}

Li, Wen ^{[1
]}

Xu, Wu-Shuang ^{[1
]}

Long, Jian-Ying ^{[3
]}

Liu, Qing-Bo ^{[3
]}

Sun, Wei-Yin ^{[2
]}

Anson, Christopher E. ^{[4
]}

Powell, Annie K. ^{[4
]}

机构：

[1] Nanjing Forestry Univ, Coll Chem Engn, Nanjing 210037, Jiangsu, Peoples R China

[2] Nanjing Univ, Inst Coordinat Chem, State Key Lab Coordinat Chem, Nanjing 210093, Jiangsu, Peoples R China

[3] Nanjing Forestry Univ, Coll Sci, Nanjing 210037, Jiangsu, Peoples R China

[4] Karlsruhe Inst Technol, Inst Inorgan Chem, D-76131 Karlsruhe, Germany

来源：

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2013年 / 34期

关键词：

Cytotoxicity; DNA binding; Copper; Structure elucidation; Chirality; CU-II; NI-II; LIGAND; CU(II); CLEAVAGE; ZN(II); ANTIOXIDANT; NI(II);

D O I：

10.1002/ejic.201300685

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Two chiral copper-(II) complexes [Cu(L)(2)Cl]Cl (1) and [Cu(L)(2)Br]Br (2) [L = N-[(pyridin-2-ylmethylene)imino]dehydroabietylamine} have been synthesized and fully characterized. The coordination geometry of the Cu-II ions in 1 and 2 can be described as an intermediate between squarepyramidal and trigonal-bipyramidal. DNA binding studies suggest that the complexes interact with salmon-sperm DNA. through intercalation, and 2 exhibits a higher binding affinity. The new complexes were screened for their antibacterial and cytotoxic ability. They have similar cytotoxic activity and they represent the first rosin-derivative-based simple Schiff base complexes with strong anticancer potential.

引用

页码：5919 / 5927

页数：9

共 29 条

[1] Ligational behaviour of lomefloxacin drug towards Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Th(IV) and UO2(VI) ions: Synthesis, structural characterization and biological activity studies [J].

Abd El-Halim, Hanan F. ;

Mohamed, Gehad G. ;

EI-Dessouky, Maher M. I. ;

Mahmoud, Walaa H. .

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2011, 82 (01) :8-19

[2] Synthesis, characterization, biological studies (DNA binding, cleavage, antibacterial and topoisomerase I) and molecular docking of copper(II) benzimidazole complexes [J].

Arjmand, Farukh ;

Parveen, Shazia ;

Afzal, Mohd ;

Shahid, Mohd .

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2012, 114 :15-26

[3] Synthesis and characterization of dinuclear macrocyclic cobalt(II), copper(II) and zinc(II) complexes derived from 2,2,2′,2′-S,S[bis(bis-N,N-2-thiobenzimidazolyloxalato-1,2-ethane)]: DNA binding and cleavage studies [J].

Arjmand, Farukh ;

Aziz, Mubashira .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (02) :834-844

[4] Mechanochemical synthesis in copper(II) halide/pyridine systems: single crystal X-ray diffraction and IR spectroscopic studies [J].

Bowmaker, Graham A. ;

Di Nicola, Corrado ;

Pettinari, Claudio ;

Skelton, Brian W. ;

Somers, Neil ;

White, Allan H. .

DALTON TRANSACTIONS, 2011, 40 (18) :5102-5115

[5] Synthesis and spectroscopy of CoII, NiII, CuII and ZnII complexes derived from 3,5-disubstituted-1H-pyrazole derivative: A special emphasis on DNA binding and cleavage studies [J].

Budagumpi, Srinivasa ;

Kulkarni, Naveen V. ;

Kurdekar, Gurunath S. ;

Sathisha, M. P. ;

Revankar, Vidyanand K. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (02) :455-462

[6] Potential new inorganic antitumour agents from combining the anticancer traditional Chinese medicine (TCM) matrine with Ga(III), Au(III), Sn(IV) ions, and DNA binding studies [J].

Chen, Zhen-Feng ;

Mao, Li ;

Liu, Li-Min ;

Liu, Yan-Cheng ;

Peng, Yan ;

Hong, Xue ;

Wang, Hong-Hong ;

Liu, Hua-Gang ;

Liang, Hong .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2011, 105 (02) :171-180

[7] Transition metal complexes of new glyoxylato-aroylhydrazones and their role in L-ascorbic acid oxidation inhibition [J].

Csonka, Robert ;

Villalonga-Barber, Carolina ;

Psycharis, Vassilis ;

Raptopoulou, Catherine P. ;

Steele, Barry R. .

POLYHEDRON, 2012, 34 (01) :181-187

[8]

Fei BaoLi Fei BaoLi, 2012, Chemistry and Industry of Forest Products, V32, P1

[9] Hairpin-shaped tetranuclear palladium(II) complex: Synthesis, crystal structure, DNA binding and cytotoxicity activity studies [J].

Gao, En-Jun ;

Wang, Ke-Hua ;

Zhu, Ming-Chang ;

Liu, Lei .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (07) :2784-2790

[10] DNA interactions of a functionalized ruthenium(II) mixed-polypyridyl complex [Ru(bpy)2ppd]2+ [J].

Gao, Feng ;

Chao, Hui ;

Zhou, Feng ;

Yuan, Yi-Xian ;

Peng, Bin ;

Ji, Liang-Nian .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2006, 100 (09) :1487-1494

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