Palladium-Catalyzed Enantioselective Narasaka-Heck Reaction/Direct C-H Alkylation of Arenes: Iminoarylation of Alkenes

被引：91
|
作者：
Bao, Xu [1 ]
Wang, Qian [1 ]
Zhu, Jieping [1 ]
机构：
[1] Ecole Polytech Fed Lausanne, Inst Chem Sci & Engn, LSPN, SB,ISIC, BCH 5304, CH-1015 Lausanne, Switzerland
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 32期
基金：
瑞士国家科学基金会;
关键词：
asymmetric catalysis; C-H activation; dihydropyrroles; domino reactions; Narasaka-Heck reactions; C(SP(2))-H BOND ACTIVATION; ASYMMETRIC HECK; EFFICIENT SYNTHESIS; OXIME ESTERS; CYCLIZATION; DERIVATIVES; DIHYDROPYRROLES; 1-AZAAZULENES; AMINATION; ARYLATION;
D O I：
10.1002/anie.201705641
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A palladium-catalyzed reaction of gamma,delta-unsaturated oxime esters with oxadiazoles afforded dihydropyrroles in good to excellent yields through an intramolecular iminopalladation/intermolecular direct heteroarene C-H alkylation cascade. This unprecedented iminoarylation of alkenes was subsequently realized in an enantioselective manner in the presence of a chiral bidentate phosphine ligand (Synphos).
引用
收藏
页码：9577 / 9581
页数：5
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