Substantia nigra hyperechogenicity does not correlate with motor features in Parkinson's disease

被引：10
作者：
Jesus-Ribeiro, Joana [1 ,2 ]
Sargento-Freitas, Joao [1 ,2 ,3 ]
Sousa, Mario [1 ,2 ]
Silva, Fernando [1 ,2 ,3 ]
Freire, Antonio [1 ,2 ,4 ]
Januario, Cristina [1 ,2 ,4 ]
机构：
[1] Ctr Hosp Coimbra, Dept Neurol, P-3000075 Coimbra, Portugal
[2] Univ Coimbra, P-3000075 Coimbra, Portugal
[3] Ctr Hosp Coimbra, Neurosonol Lab, P-3000075 Coimbra, Portugal
[4] Univ Coimbra, Fac Med, P-3000075 Coimbra, Portugal
来源：
JOURNAL OF THE NEUROLOGICAL SCIENCES | 2016年 / 364卷
关键词：
Substantia nigra; Ultrasound; Parkinson's disease; UPDRS; BRAIN PARENCHYMA SONOGRAPHY; TRANSCRANIAL SONOGRAPHY; ESSENTIAL TREMOR; ECHOGENICITY; IRON; DISORDERS; DIAGNOSIS; MARKER; SPECT;
D O I：
10.1016/j.jns.2016.03.002
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Introduction: The evaluation of hyperechogenicity of the substantia nigra (SN) by transcranial sonography (TCS) is validated for the diagnosis of Parkinson's disease (PD). However, its correlation with the severity of motor involvement is still uncertain. Methods: We included patients with clinical diagnosis of idiopathic PD in a cross-sectional study. All patients were evaluated with Unified Parkinson's Disease Rating Scale-motor score (UPDRS-III) and TCS at the same day with measurement of the area of SN hyperechogenicity for each side. We analysed the association between the area of SN hyperechogenicity and the contralateral motor scores of UPDRS-III, adjusting for age and dominance of the patient (statistical significance set to p < 0.05). Results: 35 patients were analysed, 3 (8.6%) were excluded due to poor temporal acoustic bone window. From a total of 32 patients, the mean age was 58.4 (+/- 11.2) years. The mean area of SN hyperechogenicity was: right 0.26 (+/- 0.12) cm(2) and left 0.27 (+/- 0.07) cm(2). The mean score of UPDRS-III was 18.9 (+/- 6.1). There were no statistically significant association between the scores of the UPDRS-III (rigidity, tremor and bradykinesia) and the contralateral area of SN hyperechogenicity. Conclusion: The area of SN hyperechogenicity did not correlate with motor deterioration in Parkinson's disease. (C) 2016 Elsevier B.V. All rights reserved.
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页码：9 / 11
页数：3
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