Regional vulnerability to lipoxidative damage and inflammation in normal human brain aging

被引：24

作者：

Dominguez-Gonzalez, Mayelin ^{[1
]}

Puigpinos, Meritxell ^{[1
]}

Jove, Mariona ^{[2
]}

Naudi, Alba ^{[2
]}

Portero-Otin, Manuel ^{[2
]}

Pamplona, Reinald ^{[2
]}

Ferrer, Isidro ^{[1
,3
,4
,5
]}

机构：

[1] Bellvitge Univ Hosp, Biomed Res Inst Bellvitge IDIBELL, Inst Neuropathol, Lhospitalet De Llobregat, Spain

[2] Univ Lleida, Biomed Res Inst Lleida, Dept Expt Med, UdL IRBLLeida, Lleida 25198, Spain

[3] Univ Barcelona, Dept Pathol & Expt Therapeut, C Feixa LLarga Sn, Lhospitalet De Llobregat, Spain

[4] Spanish Minist Sci & Innovat, Inst Carlos III, Biomed Res Network Ctr Neurodegenerat Dis CIBERNE, Madrid, Spain

[5] Univ Barcelona, Inst Neurosci, Lhospitalet De Llobregat, Spain

来源：

EXPERIMENTAL GERONTOLOGY | 2018年 / 111卷

关键词：

Brain aging; Oxidative stress; MDA; NKT; Regional vulnerability; COX-2; Neuroinflammation; CYP2J2; Neuroprotection; OXIDATIVE STRESS; CYCLOOXYGENASE-2; COX-2; ALZHEIMER-DISEASE; FREE-RADICALS; WHITE-MATTER; AGE; EXPRESSION; NEURONS; NEUROINFLAMMATION; IDENTIFICATION;

D O I：

10.1016/j.exger.2018.07.023

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Oxidative damage and inflammation coexist in healthy human brain aging. The present study analyzes levels of protein adduction by lipid peroxidation (LP) end-products neuroketal (NKT) and malondialdehyde (MDA), as markers of protein oxidative damage, cycloxygenase-2 (COX-2) levels, as a marker of inflammation, and cytochrome P450 2J2 (CYP2J2), responsible of generation of neuroprotective products, in twelve brain regions in normal middle-aged individuals (MA) and old-aged (OA) individuals. In addition, levels of these markers were evaluated as a function of age as a continuous variable and correction for multiple comparisons. Selection of regions was based on their different vulnerability to prevalent neurodegenerative diseases in aging. Our findings show region-dependent LP end-products, COX-2 and CYP2J2 changes in the aging human brain. However, no clear relationship can be established between NKT, MDA, COX-2 and CYP2J2 levels, and regional vulnerability to neurodegeneration in old age.

引用

页码：218 / 228

页数：11

共 70 条

[1] AGING AND PROTEIN OXIDATIVE DAMAGE [J].