The Chinese Herbal Medicine Formula mKG Suppresses Pulmonary Fibrosis of Mice Induced by Bleomycin

被引：26

作者：

Gao, Ying ^{[1
,2
,3
]}

Yao, Li-Fu ^{[3
]}

Zhao, Yang ^{[4
]}

Wei, Li-Man ^{[1
,2
]}

Guo, Peng ^{[3
]}

Yu, Meng ^{[1
,2
]}

Cao, Bo ^{[3
]}

Li, Tan ^{[3
]}

Chen, Hong ^{[3
]}

Zou, Zhong-Mei ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China

[2] Peking Union Med Coll, Beijing 100193, Peoples R China

[3] Logist Coll Chinese Peoples Armed Police Force, Dept Pharm, Tianjin 300309, Peoples R China

[4] Tianjin Univ Tradit Chinese Med, Tianjin 300193, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2016年 / 17卷 / 02期

基金：

中国博士后科学基金; 北京市自然科学基金;

关键词：

pulmonary fibrosis; bleomycin; mKG (Modified Kushen Gancao Formula); mice; INDUCED LUNG FIBROSIS; LICOCHALCONE-A; CANCER CELLS; INFLAMMATION; OXYMATRINE; GROWTH; PATHOGENESIS; ATTENUATION; INHIBITION; MECHANISMS;

D O I：

10.3390/ijms17020238

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pulmonary fibrosis (PF) is a serious progressive lung disease and it originates from inflammation-induced parenchymal injury with excessive extracellular matrix deposition to result in the destruction of the normal lung architecture. Modified Kushen Gancao Formula (mKG), derived from traditional Chinese herbal medicine, has a prominent anti-inflammatory effect. The present study is to explore the inhibitory effects of mKG on bleomycin (BLM)-induced pulmonary fibrosis in mice. mKG significantly decreased pulmonary alveolitis, fibrosis scores, and interleukin-6 (IL-6), interleukin-17 (IL-17), transforming growth factor- (TGF-) and hydroxyproline (HYP) levels in lung tissue of mice compared with BLM treatment. It markedly alleviated the increase of HYP content in the lung tissues and pathologic changes of pulmonary fibrosis caused by BLM instillation. In conclusion, mKG has an anti-fibrotic effect and might be employed as a therapeutic candidate agent for attenuating pulmonary fibrosis.

引用

页数：12

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