HIV-1 tuberculosis-associated immune reconstitution inflammatory syndrome

被引：66
作者：
Lai, Rachel P. J. [1 ]
Meintjes, Graeme [2 ,3 ,4 ]
Wilkinson, Robert J. [1 ,2 ,3 ,4 ]
机构：
[1] Francis Crick Inst, Mill Hill Lab, London NW7 1AA, England
[2] Univ Cape Town, Fac Hlth Sci, Inst Infect Dis & Mol Med, Observ, Room 3-03-05,Wolfson Pavil,Anzio Rd, ZA-7925 Cape Town, South Africa
[3] Univ London Imperial Coll Sci Technol & Med, Dept Med, London W2 1PG, England
[4] Univ Cape Town, Dept Med, Observ, ZA-7925 Cape Town, South Africa
来源：
SEMINARS IN IMMUNOPATHOLOGY | 2016年 / 38卷 / 02期
基金：
新加坡国家研究基金会; 英国医学研究理事会; 英国惠康基金;
关键词：
HIV-1; infection; Tuberculosis; Immune reconstitution inflammatory syndrome; Drug therapy-complications; ACTIVE ANTIRETROVIRAL THERAPY; IMMUNODEFICIENCY-VIRUS-INFECTION; CD4(+) T-CELLS; GENE-EXPRESSION PROFILES; TOLL-LIKE RECEPTOR; VITAMIN-D STATUS; MYCOBACTERIUM-TUBERCULOSIS; RESTORATION-DISEASE; PULMONARY TUBERCULOSIS; RISK-FACTORS;
D O I：
10.1007/s00281-015-0532-2
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Patients co-infected with HIV-1 and tuberculosis (TB) are at risk of developing TB-associated immune reconstitution inflammatory syndrome (TB-IRIS) following commencement of antiretroviral therapy (ART). TB-IRIS is characterized by transient but severe localized or systemic inflammatory reactions against Mycobacterium tuberculosis antigens. Here, we review the risk factors and clinical management of TB-IRIS, as well as the roles played by different aspects of the immune response in contributing to TB-IRIS pathogenesis.
引用
收藏
页码：185 / 198
页数：14
相关论文
共 147 条
[21]   Paradoxical reactions during tuberculosis treatment in patients with and without HIV co-infection [J].
Breen, RAM ;
Smith, CJ ;
Bettinson, H ;
Dart, S ;
Bannister, B ;
Johnson, MA ;
Lipman, MCI .
THORAX, 2004, 59 (08) :704-707
[22]   Determinants of immune reconstitution inflammatory syndrome in HIV type 1 -: Infected patients with tuberculosis after initiation of antiretroviral therapy [J].
Breton, G ;
Duval, X ;
Estellat, C ;
Poaletti, X ;
Bonnet, D ;
Mvondo, DM ;
Longuet, P ;
Leport, C ;
Vildé, JL .
CLINICAL INFECTIOUS DISEASES, 2004, 39 (11) :1709-1712
[23]   Thalidomide for steroid-dependent immune reconstitution inflammatory syndromes during AIDS [J].
Brunel, Anne-Sophie ;
Reynes, Jacques ;
Tuaillon, Edouard ;
Rubbo, Pierre-Alain ;
Lortholary, Olivier ;
Montes, Brigitte ;
Le Moing, Vincent ;
Makinson, Alain .
AIDS, 2012, 26 (16) :2110-2112
[24]  
Burman W, 2007, INT J TUBERC LUNG D, V11, P1282
[25]   Activation of NKT cells protects mice from tuberculosis [J].
Chackerian, A ;
Alt, J ;
Perera, V ;
Behar, SM .
INFECTION AND IMMUNITY, 2002, 70 (11) :6302-6309
[26]   Biomarkers of CD4+ T-cell activation as risk factors for tuberculosis-associated immune reconstitution inflammatory syndrome [J].
Chakrabarti, Lisa A. ;
Boucherie, Celine ;
Bugault, Florence ;
Cumont, Marie-Christine ;
Roussillon, Caroline ;
Breton, Guillaume ;
Patey, Olivier ;
Chene, Genevieve ;
Richert, Laura ;
Lortholary, Olivier .
AIDS, 2014, 28 (11) :1593-1602
[27]   R5 and X4 HIV envelopes induce distinct gene expression profiles in primary peripheral blood mononuclear cells [J].
Cicala, C ;
Arthos, J ;
Martinelli, E ;
Censoplano, N ;
Cruz, CC ;
Chung, E ;
Selig, SM ;
Van Ryk, D ;
Yang, J ;
Jagannatha, S ;
Chun, TW ;
Ren, P ;
Lempicki, RA ;
Fauci, AS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (10) :3746-3751
[28]  
Colebunders R, 2006, INT J TUBERC LUNG D, V10, P946
[29]   Corticosteroid Therapy, Vitamin D Status, and Inflammatory Cytokine Profile in the HIV-Tuberculosis Immune Reconstitution Inflammatory Syndrome [J].
Conesa-Botella, Anali ;
Meintjes, Graeme ;
Coussens, Anna K. ;
van der Plas, Helen ;
Goliath, Rene ;
Schutz, Charlotte ;
Moreno-Reyes, Rodrigo ;
Mehta, Meera ;
Martineau, Adrian R. ;
Wilkinson, Robert J. ;
Colebunders, Robert ;
Wilkinson, Katalin A. .
CLINICAL INFECTIOUS DISEASES, 2012, 55 (07) :1004-1011
[30]   Natural Killer Cell Activation Distinguishes Mycobacterium tuberculosis-Mediated Immune Reconstitution Syndrome From Chronic HIV and HIV/MTB Coinfection [J].
Conradie, Francesca ;
Foulkes, Andrea S. ;
Ive, Prudence ;
Yin, Xiangfan ;
Roussos, Katerina ;
Glencross, Deborah K. ;
Lawrie, Denise ;
Stevens, Wendy ;
Montaner, Luis J. ;
Sanne, Ian ;
Azzoni, Livio .
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2011, 58 (03) :309-318
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