HIV-1 tuberculosis-associated immune reconstitution inflammatory syndrome

被引：66
作者：
Lai, Rachel P. J. [1 ]
Meintjes, Graeme [2 ,3 ,4 ]
Wilkinson, Robert J. [1 ,2 ,3 ,4 ]
机构：
[1] Francis Crick Inst, Mill Hill Lab, London NW7 1AA, England
[2] Univ Cape Town, Fac Hlth Sci, Inst Infect Dis & Mol Med, Observ, Room 3-03-05,Wolfson Pavil,Anzio Rd, ZA-7925 Cape Town, South Africa
[3] Univ London Imperial Coll Sci Technol & Med, Dept Med, London W2 1PG, England
[4] Univ Cape Town, Dept Med, Observ, ZA-7925 Cape Town, South Africa
来源：
SEMINARS IN IMMUNOPATHOLOGY | 2016年 / 38卷 / 02期
基金：
新加坡国家研究基金会; 英国医学研究理事会; 英国惠康基金;
关键词：
HIV-1; infection; Tuberculosis; Immune reconstitution inflammatory syndrome; Drug therapy-complications; ACTIVE ANTIRETROVIRAL THERAPY; IMMUNODEFICIENCY-VIRUS-INFECTION; CD4(+) T-CELLS; GENE-EXPRESSION PROFILES; TOLL-LIKE RECEPTOR; VITAMIN-D STATUS; MYCOBACTERIUM-TUBERCULOSIS; RESTORATION-DISEASE; PULMONARY TUBERCULOSIS; RISK-FACTORS;
D O I：
10.1007/s00281-015-0532-2
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Patients co-infected with HIV-1 and tuberculosis (TB) are at risk of developing TB-associated immune reconstitution inflammatory syndrome (TB-IRIS) following commencement of antiretroviral therapy (ART). TB-IRIS is characterized by transient but severe localized or systemic inflammatory reactions against Mycobacterium tuberculosis antigens. Here, we review the risk factors and clinical management of TB-IRIS, as well as the roles played by different aspects of the immune response in contributing to TB-IRIS pathogenesis.
引用
收藏
页码：185 / 198
页数：14
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