A 'click chemistry' approach to the efficient synthesis of modified nucleosides and oligonucleotides for PET imaging

被引：23

作者：

James, Damien ^{[1
]}

Escudier, Jean-Marc ^{[2
]}

Amigues, Eric ^{[1
]}

Schulz, Juergen ^{[3
]}

Vitry, Christiane ^{[1
]}

Bordenave, Thomas ^{[1
]}

Szlosek-Pinaud, Magali ^{[1
]}

Fouquet, Eric ^{[1
]}

机构：

[1] Univ Bordeaux, CNRS, UMR 5255, Inst Mol Sci, F-33405 Talence, France

[2] Univ Toulouse 3, CNRS, UMR 5068, LSPCMIB, F-31062 Toulouse, France

[3] Univ Bordeaux, CNRS, UMR 5231, LIMF, F-33076 Bordeaux, France

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 08期

关键词：

REAGENTS; C-11;

D O I：

10.1016/j.tetlet.2009.12.120

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Different thymidine derivatives bearing either an iodoaryl moiety at the 5' position or a dialkylsilyl group at the 3' position have been efficiently synthesized as precursors for carbon-11 or fluorine-18 labeling, respectively. Furthermore, iodoarylated thymidine derivatives have been incorporated into oligonucleotides giving an original way to label them with carbon-11. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1230 / 1232

页数：3

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