共 46 条
E-selectin-targeting delivery of microRNAs by microparticles ameliorates endothelial inflammation and atherosclerosis
被引:136
作者:

Ma, Shuangtao
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机构:
Houston Methodist Res Inst, Dept Cardiovasc Sci, Houston, TX 77030 USA Houston Methodist Res Inst, Dept Cardiovasc Sci, Houston, TX 77030 USA

Tian, Xiao Yu
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机构:
Houston Methodist Res Inst, Dept Cardiovasc Sci, Houston, TX 77030 USA
Chinese Univ Hong Kong, Sch Biomed Sci, Inst Vasc Med, Shatin, Hong Kong, Peoples R China
Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Shatin, Hong Kong, Peoples R China Houston Methodist Res Inst, Dept Cardiovasc Sci, Houston, TX 77030 USA

Zhang, Yunrong
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Houston Methodist Res Inst, Dept Cardiovasc Sci, Houston, TX 77030 USA Houston Methodist Res Inst, Dept Cardiovasc Sci, Houston, TX 77030 USA

Mu, Chaofeng
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Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA Houston Methodist Res Inst, Dept Cardiovasc Sci, Houston, TX 77030 USA

Shen, Haifa
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Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA Houston Methodist Res Inst, Dept Cardiovasc Sci, Houston, TX 77030 USA

Bismuth, Jean
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Houston Methodist Hosp, Methodist DeBakey Heart & Vasc Ctr, Houston, TX 77030 USA Houston Methodist Res Inst, Dept Cardiovasc Sci, Houston, TX 77030 USA

Pownall, Henry J.
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Houston Methodist Res Inst, Dept Cardiovasc Sci, Houston, TX 77030 USA Houston Methodist Res Inst, Dept Cardiovasc Sci, Houston, TX 77030 USA

Huang, Yu
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h-index: 0
机构:
Chinese Univ Hong Kong, Sch Biomed Sci, Inst Vasc Med, Shatin, Hong Kong, Peoples R China
Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Shatin, Hong Kong, Peoples R China Houston Methodist Res Inst, Dept Cardiovasc Sci, Houston, TX 77030 USA

Wong, Wing Tak
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h-index: 0
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Houston Methodist Res Inst, Dept Cardiovasc Sci, Houston, TX 77030 USA Houston Methodist Res Inst, Dept Cardiovasc Sci, Houston, TX 77030 USA
机构:
[1] Houston Methodist Res Inst, Dept Cardiovasc Sci, Houston, TX 77030 USA
[2] Chinese Univ Hong Kong, Sch Biomed Sci, Inst Vasc Med, Shatin, Hong Kong, Peoples R China
[3] Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Shatin, Hong Kong, Peoples R China
[4] Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA
[5] Houston Methodist Hosp, Methodist DeBakey Heart & Vasc Ctr, Houston, TX 77030 USA
来源:
关键词:
IN-VIVO;
ADHESION MOLECULES;
NANOPARTICLES;
FLOW;
THERAPY;
CELL;
NEOVASCULARIZATION;
INHIBITION;
D O I:
10.1038/srep22910
中图分类号:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
E-selectin is a surface marker of endothelial cell (EC) inflammation, one of the hallmarks of atherogenesis. Thus, we tested the hypothesis that delivery of microRNA (miR)-146a and miR-181b with an E-selectin-targeting multistage vector (ESTA-MSV) to inflamed endothelium covering atherosclerotic plaques inhibits atherosclerosis. Cy5-conjugated miR-146a and miR-181b were packaged in polyethylene glycol-polyethyleneimine (PEG/PEI) nanoparticles and loaded into ESTA-MSV microparticles. Both miRs were downregulated in tumor necrosis factor (TNF)-alpha-treated ECs. Transfection of TNF-alpha-treated mouse aortas and cultured ECs with miRs was more efficient with ESTA-MSV than with the PEG/PEI. Likewise, miR-146a/-181b packaged in ESTA-MSV efficiently suppressed the chemokines, CCL2, CCL5, CCL8, and CXCL9, and monocyte adhesion to ECs. Complementary in vivo tests were conducted in male apolipoprotein E-deficient mice fed a Western diet and injected intravenously with the particles prepared as above biweekly for 12 weeks. Treatment with miRs packaged in ESTA-MSV but not in PEG/PEI reduced atherosclerotic plaque size. Concurrently, vascular inflammation markers, including macrophages in aortic root lesions and chemokine expression in aortic tissues were reduced while the vascular smooth muscle cells and collagen increased in plaques from ESTA-MSV/miRs-treated vs. vehicle-treated mice. Our data supported our hypothesis that ESTA-MSV microparticle-mediated delivery of miR-146a/-181b ameliorates endothelial inflammation and atherosclerosis.
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页数:11
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共 46 条
[21]
Sugar-based amphiphilic nanoparticles arrest atherosclerosis in vivo
[J].
Lewis, Daniel R.
;
Petersen, Latrisha K.
;
York, Adam W.
;
Zablocki, Kyle R.
;
Joseph, Laurie B.
;
Kholodovych, Vladyslav
;
Prud'homme, Robert K.
;
Uhrich, Kathryn E.
;
Moghe, Prabhas V.
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2015, 112 (09)
:2693-2698

Lewis, Daniel R.
论文数: 0 引用数: 0
h-index: 0
机构:
Rutgers State Univ, Dept Chem & Biochem Engn, Piscataway, NJ 08854 USA
Rutgers State Univ, Dept Biomed Engn, Piscataway, NJ 08854 USA Rutgers State Univ, Dept Chem & Biochem Engn, Piscataway, NJ 08854 USA

Petersen, Latrisha K.
论文数: 0 引用数: 0
h-index: 0
机构:
Rutgers State Univ, Dept Biomed Engn, Piscataway, NJ 08854 USA Rutgers State Univ, Dept Chem & Biochem Engn, Piscataway, NJ 08854 USA

York, Adam W.
论文数: 0 引用数: 0
h-index: 0
机构:
Rutgers State Univ, Dept Biomed Engn, Piscataway, NJ 08854 USA Rutgers State Univ, Dept Chem & Biochem Engn, Piscataway, NJ 08854 USA

Zablocki, Kyle R.
论文数: 0 引用数: 0
h-index: 0
机构:
Rutgers State Univ, Dept Biomed Engn, Piscataway, NJ 08854 USA Rutgers State Univ, Dept Chem & Biochem Engn, Piscataway, NJ 08854 USA

Joseph, Laurie B.
论文数: 0 引用数: 0
h-index: 0
机构:
Rutgers State Univ, Dept Pharmacol, Piscataway, NJ 08854 USA Rutgers State Univ, Dept Chem & Biochem Engn, Piscataway, NJ 08854 USA

Kholodovych, Vladyslav
论文数: 0 引用数: 0
h-index: 0
机构:
Rutgers State Univ, Div High Performance & Res Comp, Off Informat Technol, Piscataway, NJ 08854 USA Rutgers State Univ, Dept Chem & Biochem Engn, Piscataway, NJ 08854 USA

Prud'homme, Robert K.
论文数: 0 引用数: 0
h-index: 0
机构:
Princeton Univ, Dept Chem & Biomol Engn, Princeton, NJ 08544 USA Rutgers State Univ, Dept Chem & Biochem Engn, Piscataway, NJ 08854 USA

Uhrich, Kathryn E.
论文数: 0 引用数: 0
h-index: 0
机构:
Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ 08854 USA Rutgers State Univ, Dept Chem & Biochem Engn, Piscataway, NJ 08854 USA

Moghe, Prabhas V.
论文数: 0 引用数: 0
h-index: 0
机构:
Rutgers State Univ, Dept Chem & Biochem Engn, Piscataway, NJ 08854 USA
Rutgers State Univ, Dept Biomed Engn, Piscataway, NJ 08854 USA Rutgers State Univ, Dept Chem & Biochem Engn, Piscataway, NJ 08854 USA
[22]
Apolipoprotein E Enhances MicroRNA-146a in Monocytes and Macrophages to Suppress Nuclear Factor-κB-Driven Inflammation and Atherosclerosis
[J].
Li, Kang
;
Ching, Daniel
;
Luk, Fu Sang
;
Raffai, Robert L.
.
CIRCULATION RESEARCH,
2015, 117 (01)
:e1-e11

Li, Kang
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Dept Surg, Div Vasc & Endovasc Surg, San Francisco, CA 94121 USA

Ching, Daniel
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Dept Surg, Div Vasc & Endovasc Surg, San Francisco, CA 94121 USA

Luk, Fu Sang
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Dept Surg, Div Vasc & Endovasc Surg, San Francisco, CA 94121 USA

Raffai, Robert L.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Dept Surg, Div Vasc & Endovasc Surg, San Francisco, CA 94121 USA
[23]
Inflammation and atherosclerosis
[J].
Libby, P
;
Ridker, PM
;
Maseri, A
.
CIRCULATION,
2002, 105 (09)
:1135-1143

Libby, P
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Brigham & Womens Hosp, Leducq Ctr Cardiovasc Res,Dept Med, Boston, MA 02115 USA

Ridker, PM
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Brigham & Womens Hosp, Leducq Ctr Cardiovasc Res,Dept Med, Boston, MA 02115 USA

Maseri, A
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Brigham & Womens Hosp, Leducq Ctr Cardiovasc Res,Dept Med, Boston, MA 02115 USA
[24]
Atherosclerotic Plaque Targeting Mechanism of Long-Circulating Nanoparticles Established by Multimodal Imaging
[J].
Lobatto, Mark E.
;
Calcagno, Claudia
;
Millon, Antoine
;
Senders, Max L.
;
Fay, Francois
;
Robson, Philip M.
;
Ramachandran, Sarayu
;
Binderup, Tina
;
Paridaans, Maarten P. M.
;
Sensarn, Steven
;
Rogalla, Stephan
;
Gordon, Ronald E.
;
Cardoso, Luis
;
Storm, Gert
;
Metselaar, Josbert M.
;
Contag, Christopher H.
;
Stroes, Erik S. G.
;
Fayad, Zahi A.
;
Mulder, Willem J. M.
.
ACS NANO,
2015, 9 (02)
:1837-1847

Lobatto, Mark E.
论文数: 0 引用数: 0
h-index: 0
机构:
Icahn Sch Med Mt Sinai, Dept Radiol, Translat & Mol Imaging Inst, New York, NY 10029 USA
Univ Amsterdam, Acad Med Ctr, Dept Vasc Med, NL-1105 AZ Amsterdam, Netherlands Icahn Sch Med Mt Sinai, Dept Radiol, Translat & Mol Imaging Inst, New York, NY 10029 USA

Calcagno, Claudia
论文数: 0 引用数: 0
h-index: 0
机构:
Icahn Sch Med Mt Sinai, Dept Radiol, Translat & Mol Imaging Inst, New York, NY 10029 USA Icahn Sch Med Mt Sinai, Dept Radiol, Translat & Mol Imaging Inst, New York, NY 10029 USA

Millon, Antoine
论文数: 0 引用数: 0
h-index: 0
机构:
Icahn Sch Med Mt Sinai, Dept Radiol, Translat & Mol Imaging Inst, New York, NY 10029 USA
Univ Hosp Lyon, Dept Vasc Surg, F-69000 Lyon, France Icahn Sch Med Mt Sinai, Dept Radiol, Translat & Mol Imaging Inst, New York, NY 10029 USA

Senders, Max L.
论文数: 0 引用数: 0
h-index: 0
机构:
Icahn Sch Med Mt Sinai, Dept Radiol, Translat & Mol Imaging Inst, New York, NY 10029 USA Icahn Sch Med Mt Sinai, Dept Radiol, Translat & Mol Imaging Inst, New York, NY 10029 USA

Fay, Francois
论文数: 0 引用数: 0
h-index: 0
机构:
Icahn Sch Med Mt Sinai, Dept Radiol, Translat & Mol Imaging Inst, New York, NY 10029 USA Icahn Sch Med Mt Sinai, Dept Radiol, Translat & Mol Imaging Inst, New York, NY 10029 USA

Robson, Philip M.
论文数: 0 引用数: 0
h-index: 0
机构:
Icahn Sch Med Mt Sinai, Dept Radiol, Translat & Mol Imaging Inst, New York, NY 10029 USA Icahn Sch Med Mt Sinai, Dept Radiol, Translat & Mol Imaging Inst, New York, NY 10029 USA

Ramachandran, Sarayu
论文数: 0 引用数: 0
h-index: 0
机构:
Icahn Sch Med Mt Sinai, Dept Radiol, Translat & Mol Imaging Inst, New York, NY 10029 USA Icahn Sch Med Mt Sinai, Dept Radiol, Translat & Mol Imaging Inst, New York, NY 10029 USA

论文数: 引用数:
h-index:
机构:

Paridaans, Maarten P. M.
论文数: 0 引用数: 0
h-index: 0
机构:
Icahn Sch Med Mt Sinai, Dept Radiol, Translat & Mol Imaging Inst, New York, NY 10029 USA Icahn Sch Med Mt Sinai, Dept Radiol, Translat & Mol Imaging Inst, New York, NY 10029 USA

Sensarn, Steven
论文数: 0 引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Radiol, Stanford, CA 94305 USA
Stanford Univ, Mol Imaging Program, Stanford, CA 94305 USA Icahn Sch Med Mt Sinai, Dept Radiol, Translat & Mol Imaging Inst, New York, NY 10029 USA

Rogalla, Stephan
论文数: 0 引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Radiol, Stanford, CA 94305 USA
Stanford Univ, Mol Imaging Program, Stanford, CA 94305 USA Icahn Sch Med Mt Sinai, Dept Radiol, Translat & Mol Imaging Inst, New York, NY 10029 USA

Gordon, Ronald E.
论文数: 0 引用数: 0
h-index: 0
机构:
Mt Sinai Hosp, Dept Pathol, New York, NY 10029 USA Icahn Sch Med Mt Sinai, Dept Radiol, Translat & Mol Imaging Inst, New York, NY 10029 USA

Cardoso, Luis
论文数: 0 引用数: 0
h-index: 0
机构:
CUNY City Coll, Dept Biomed Engn, New York, NY 10031 USA Icahn Sch Med Mt Sinai, Dept Radiol, Translat & Mol Imaging Inst, New York, NY 10029 USA

Storm, Gert
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Twente, MIRA Inst, Dept Targeted Therapeut, NL-7500 AE Enschede, Netherlands
Univ Utrecht, Utrecht Inst Pharmaceut Sci, NL-3512 JE Utrecht, Netherlands Icahn Sch Med Mt Sinai, Dept Radiol, Translat & Mol Imaging Inst, New York, NY 10029 USA

Metselaar, Josbert M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Twente, MIRA Inst, Dept Targeted Therapeut, NL-7500 AE Enschede, Netherlands Icahn Sch Med Mt Sinai, Dept Radiol, Translat & Mol Imaging Inst, New York, NY 10029 USA

Contag, Christopher H.
论文数: 0 引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Radiol, Stanford, CA 94305 USA
Stanford Univ, Mol Imaging Program, Stanford, CA 94305 USA Icahn Sch Med Mt Sinai, Dept Radiol, Translat & Mol Imaging Inst, New York, NY 10029 USA

Stroes, Erik S. G.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Amsterdam, Acad Med Ctr, Dept Vasc Med, NL-1105 AZ Amsterdam, Netherlands Icahn Sch Med Mt Sinai, Dept Radiol, Translat & Mol Imaging Inst, New York, NY 10029 USA

Fayad, Zahi A.
论文数: 0 引用数: 0
h-index: 0
机构:
Icahn Sch Med Mt Sinai, Dept Radiol, Translat & Mol Imaging Inst, New York, NY 10029 USA Icahn Sch Med Mt Sinai, Dept Radiol, Translat & Mol Imaging Inst, New York, NY 10029 USA

Mulder, Willem J. M.
论文数: 0 引用数: 0
h-index: 0
机构:
Icahn Sch Med Mt Sinai, Dept Radiol, Translat & Mol Imaging Inst, New York, NY 10029 USA
Univ Amsterdam, Acad Med Ctr, Dept Vasc Med, NL-1105 AZ Amsterdam, Netherlands Icahn Sch Med Mt Sinai, Dept Radiol, Translat & Mol Imaging Inst, New York, NY 10029 USA
[25]
Bone marrow endothelium-targeted therapeutics for metastatic breast cancer
[J].
Mai, Junhua
;
Huang, Yi
;
Mu, Chaofeng
;
Zhang, Guodong
;
Xu, Rong
;
Guo, Xiaojing
;
Xia, Xiaojun
;
Volk, David E.
;
Lokesh, Ganesh L.
;
Thiviyanathan, Varatharasa
;
Gorenstein, David G.
;
Liu, Xuewu
;
Ferrari, Mauro
;
Shen, Haifa
.
JOURNAL OF CONTROLLED RELEASE,
2014, 187
:22-29

Mai, Junhua
论文数: 0 引用数: 0
h-index: 0
机构:
Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA

Huang, Yi
论文数: 0 引用数: 0
h-index: 0
机构:
Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA
Third Mil Med Univ, Biomed Anal Ctr, Chongqing 400038, Peoples R China Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA

Mu, Chaofeng
论文数: 0 引用数: 0
h-index: 0
机构:
Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA

Zhang, Guodong
论文数: 0 引用数: 0
h-index: 0
机构:
Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA

Xu, Rong
论文数: 0 引用数: 0
h-index: 0
机构:
Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA

Guo, Xiaojing
论文数: 0 引用数: 0
h-index: 0
机构:
Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA
Tianjin Med Univ, Canc Inst & Hosp, Dept Breast Canc Pathol, Tianjin 300060, Peoples R China
Tianjin Med Univ, Canc Inst & Hosp, Res Lab, Key Lab Breast Canc Breast Canc Prevent & Therapy, Tianjin 300060, Peoples R China Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA

Xia, Xiaojun
论文数: 0 引用数: 0
h-index: 0
机构:
Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA

Volk, David E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas Houston, Hlth Sci Ctr, Inst Mol Med, Houston, TX 77030 USA Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA

Lokesh, Ganesh L.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas Houston, Hlth Sci Ctr, Inst Mol Med, Houston, TX 77030 USA Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA

Thiviyanathan, Varatharasa
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas Houston, Hlth Sci Ctr, Inst Mol Med, Houston, TX 77030 USA Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA

Gorenstein, David G.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas Houston, Hlth Sci Ctr, Inst Mol Med, Houston, TX 77030 USA Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA

Liu, Xuewu
论文数: 0 引用数: 0
h-index: 0
机构:
Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA

Ferrari, Mauro
论文数: 0 引用数: 0
h-index: 0
机构:
Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA
Weill Cornell Med Coll, Dept Med, New York, NY 10065 USA Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA

Shen, Haifa
论文数: 0 引用数: 0
h-index: 0
机构:
Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA
Weill Cornell Med Coll, Dept Cell & Dev Biol, New York, NY 10065 USA Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA
[26]
Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer
[J].
Malam, Yogeshkumar
;
Loizidou, Marilena
;
Seifalian, Alexander M.
.
TRENDS IN PHARMACOLOGICAL SCIENCES,
2009, 30 (11)
:592-599

Malam, Yogeshkumar
论文数: 0 引用数: 0
h-index: 0
机构:
UCL, Ctr Nanotechnol Biomat & Tissue Engn, London, England
UCL, UCL Div Surg & Intervent Sci, London, England UCL, Ctr Nanotechnol Biomat & Tissue Engn, London, England

Loizidou, Marilena
论文数: 0 引用数: 0
h-index: 0
机构:
UCL, UCL Div Surg & Intervent Sci, London, England UCL, Ctr Nanotechnol Biomat & Tissue Engn, London, England

Seifalian, Alexander M.
论文数: 0 引用数: 0
h-index: 0
机构:
UCL, Ctr Nanotechnol Biomat & Tissue Engn, London, England
UCL, UCL Div Surg & Intervent Sci, London, England
Royal Free Hampstead NHS Trust Hosp, London, England UCL, Ctr Nanotechnol Biomat & Tissue Engn, London, England
[27]
Neovascularization in human atherosclerosis
[J].
Moreno, PR
;
Purushothaman, KR
;
Sirol, M
;
Levy, AP
;
Fuster, V
.
CIRCULATION,
2006, 113 (18)
:2245-2252

Moreno, PR
论文数: 0 引用数: 0
h-index: 0
机构: Mt Sinai Sch Med, Zena & Michael A Wiener Cardiovasc Inst, New York, NY 10029 USA

Purushothaman, KR
论文数: 0 引用数: 0
h-index: 0
机构: Mt Sinai Sch Med, Zena & Michael A Wiener Cardiovasc Inst, New York, NY 10029 USA

Sirol, M
论文数: 0 引用数: 0
h-index: 0
机构: Mt Sinai Sch Med, Zena & Michael A Wiener Cardiovasc Inst, New York, NY 10029 USA

Levy, AP
论文数: 0 引用数: 0
h-index: 0
机构: Mt Sinai Sch Med, Zena & Michael A Wiener Cardiovasc Inst, New York, NY 10029 USA

Fuster, V
论文数: 0 引用数: 0
h-index: 0
机构: Mt Sinai Sch Med, Zena & Michael A Wiener Cardiovasc Inst, New York, NY 10029 USA
[28]
Nanoparticle-mediated delivery of therapeutic genes: focus on miRNA therapeutics
[J].
Muthiah, Muthunarayanan
;
Park, In-Kyu
;
Cho, Chong-Su
.
EXPERT OPINION ON DRUG DELIVERY,
2013, 10 (09)
:1259-1273

Muthiah, Muthunarayanan
论文数: 0 引用数: 0
h-index: 0
机构:
Chonnam Natl Univ, Sch Med, Res Inst Med Sci, Dept Biomed Sci, Kwangju 501746, South Korea
Chonnam Natl Univ, Hwasun Hosp, Clin Vaccine R&D Ctr, Jeonnam 519763, South Korea Chonnam Natl Univ, Sch Med, Res Inst Med Sci, Dept Biomed Sci, Kwangju 501746, South Korea

论文数: 引用数:
h-index:
机构:

Cho, Chong-Su
论文数: 0 引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Dept Agr Biotechnol, Seoul 151921, South Korea
Seoul Natl Univ, Res Inst Agr & Life, Seoul 151921, South Korea Chonnam Natl Univ, Sch Med, Res Inst Med Sci, Dept Biomed Sci, Kwangju 501746, South Korea
[29]
In vivo evaluation of vascular-targeted spheroidal microparticles for imaging and drug delivery application in atherosclerosis
[J].
Namdee, Katawut
;
Thompson, Alex J.
;
Golinski, Alexander
;
Mocherla, Supriya
;
Bouis, Diane
;
Eniola-Adefeso, Omolola
.
ATHEROSCLEROSIS,
2014, 237 (01)
:279-286

Namdee, Katawut
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA

Thompson, Alex J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Chem Engn, Ann Arbor, MI 48109 USA Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA

Golinski, Alexander
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Chem Engn, Ann Arbor, MI 48109 USA Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA

Mocherla, Supriya
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Chem Engn, Ann Arbor, MI 48109 USA Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA

Bouis, Diane
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI USA Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA

Eniola-Adefeso, Omolola
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Chem Engn, Ann Arbor, MI 48109 USA Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA
[30]
MicroRNAs in flow-dependent vascular remodelling
[J].
Neth, Peter
;
Nazari-Jahantigh, Maliheh
;
Schober, Andreas
;
Weber, Christian
.
CARDIOVASCULAR RESEARCH,
2013, 99 (02)
:294-303

Neth, Peter
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Univ Munich, Inst Cardiovasc Prevent, D-80336 Munich, Germany Univ Munich, Inst Cardiovasc Prevent, D-80336 Munich, Germany

Nazari-Jahantigh, Maliheh
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Univ Munich, Inst Cardiovasc Prevent, D-80336 Munich, Germany Univ Munich, Inst Cardiovasc Prevent, D-80336 Munich, Germany

Schober, Andreas
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Univ Munich, Inst Cardiovasc Prevent, D-80336 Munich, Germany
Partner Site Munich Heart Alliance, DZHK German Ctr Cardiovasc Res, Munich, Germany Univ Munich, Inst Cardiovasc Prevent, D-80336 Munich, Germany

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