Overview of Alzheimer's Disease and Some Therapeutic Approaches Targeting Aβ by Using Several Synthetic and Herbal Compounds

被引：124

作者：

Singh, Sandeep Kumar ^{[1
]}

Srivastav, Saurabh ^{[1
]}

Yadav, Amarish Kumar ^{[1
]}

Srikrishna, Saripella ^{[1
]}

Perry, George ^{[2
]}

机构：

[1] Banaras Hindu Univ, Dept Biochem, Fac Sci, Varanasi 221005, Uttar Pradesh, India

[2] Univ Texas San Antonio, Dept Biol, San Antonio, TX 78249 USA

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2016年 / 2016卷

基金：

美国国家卫生研究院;

关键词：

AMYLOID PRECURSOR PROTEIN; INTRANEURONAL A-BETA-42 ACCUMULATION; TRANS-GOLGI NETWORK; GREEN TEA CATECHINS; ZINC-BINDING SITE; CHOLINERGIC HYPOTHESIS; SYNAPTIC PLASTICITY; COGNITIVE DEFICITS; NEURODEGENERATIVE DISEASES; PLAQUE-FORMATION;

D O I：

10.1155/2016/7361613

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Alzheimer's disease (AD) is a complex age-related neurodegenerative disease. In this review, we carefully detail amyloid-beta metabolism and its role in AD. We also consider the various genetic animal models used to evaluate therapeutics. Finally, we consider the role of synthetic and plant-based compounds in therapeutics.

引用

页数：22

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