A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: management strategies and economic impact

被引：182

作者：

Jensen, S. B. ^{[1
]}

Pedersen, A. M. L. ^{[1
]}

Vissink, A. ^{[2
]}

Andersen, E. ^{[3
]}

Brown, C. G. ^{[4
]}

Davies, A. N. ^{[5
]}

Dutilh, J. ^{[6
]}

Fulton, J. S. ^{[7
]}

Jankovic, L. ^{[8
]}

Lopes, N. N. F. ^{[9
]}

Mello, A. L. S. ^{[10
]}

Muniz, L. V. ^{[11
]}

Murdoch-Kinch, C. A. ^{[12
]}

Nair, R. G. ^{[13
]}

Napenas, J. J. ^{[14
]}

Nogueira-Rodrigues, A. ^{[15
]}

Saunders, D. ^{[16
]}

Stirling, B. ^{[14
]}

von Bueltzingsloewen, I. ^{[17
]}

Weikel, D. S. ^{[18
,19
]}

Elting, L. S. ^{[20
]}

Spijkervet, F. K. L. ^{[2
]}

Brennan, M. T. ^{[14
]}

机构：

[1] Univ Copenhagen, Dept Oral Med Clin Oral Physiol Oral Pathol & Ana, Inst Odontol, Fac Hlth Sci, DK-2200 Copenhagen, Denmark

[2] Univ Groningen, Dept Oral & Maxillofacial Surg, Univ Med Ctr Groningen, NL-9700 RB Groningen, Netherlands

[3] Herlev Univ Hosp, Dept Oncol, DK-2730 Herlev, Denmark

[4] Univ Delaware, Sch Nursing, Coll Hlth Sci, Newark, DE 19716 USA

[5] Royal Marsden Hosp, Dept Palliat Med, Sutton SM2 5P5, Surrey, England

[6] Dutilh Inst Reabilitacao Facial Oral, Taquaral, Brazil

[7] Indiana Univ, Sch Nursing, Dept Adult Hlth, Indianapolis, IN 46202 USA

[8] Univ Belgrade, Clin Periodontol & Oral Med, Fac Stomatol, Belgrade 11000, Serbia

[9] Univ Fed Sao Paulo, Serv Oral Med, IOP, Pediat Oncol Inst GRAACC, BR-04023062 Sao Paulo, Brazil

[10] Univ Fed Sao Paulo, Dept Endocrinol, Sao Paulo, Brazil

[11] Hosp Cancer Ctr Oeste Minas Gerais, IPOM, Dept Odontol,Inst Pesquisas Oncol Minas Gerais, Associacao Combate Cancer Ctr Oeste Minas Gerais, Minas Gerais, Brazil

[12] Univ Michigan, Dept Oral & Maxillofacial Surg, Hosp Dent, Sch Dent, Ann Arbor, MI 48109 USA

[13] Griffith Univ, Ctr Med & Oral Hlth, Gold Coast, Qld 4222, Australia

[14] Carolinas Med Ctr, Dept Oral Med, Charlotte, NC 28232 USA

[15] Hosp Cancer Ctr Oeste Minas Gerais, Dept Oncol & Res, Associacao Combate Cancer Ctr Oeste Minas Gerais, Inst Pesquisas Oncol Minas Gerais,IPOM, Minas Gerais, Brazil

[16] Hop Reg Sudbury Reg Hosp, Dept Dent, Sudbury Reg Hosp Canc Program, Sudbury, ON P3E 5J1, Canada

[17] Univ Gothenburg, Dept Oral Immunol & Oral Med, Inst Odontol, Sahlgrenska Acad, S-41390 Gothenburg, Sweden

[18] Univ Maryland, Sch Dent, Dept Pathol & Diagnost Sci, Baltimore, MD 21201 USA

[19] Greenebaum Canc Ctr, Baltimore, MD 21201 USA

[20] Univ Texas MD Anderson Canc Ctr, Dept Biostat, Houston, TX 77030 USA

来源：

SUPPORTIVE CARE IN CANCER | 2010年 / 18卷 / 08期

关键词：

Cancer therapy; Salivary gland hypofunction; Xerostomia; Management strategies; Economic impact; INTENSITY-MODULATED RADIOTHERAPY; QUALITY-OF-LIFE; RADIATION-INDUCED XEROSTOMIA; PAROTID-SPARING RADIOTHERAPY; BLIND CROSSOVER TRIAL; QUANTITATIVE PERTECHNETATE SCINTIGRAPHY; STAGE NASOPHARYNGEAL CARCINOMA; CONTAINING ARTIFICIAL SALIVA; HYPERBARIC-OXYGEN THERAPY; SAN-FRANCISCO EXPERIENCE;

D O I：

10.1007/s00520-010-0837-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This systematic review aimed to assess the literature for management strategies and economic impact of salivary gland hypofunction and xerostomia induced by cancer therapies and to determine the quality of evidence-based management recommendations. The electronic databases of MEDLINE/PubMed and EMBASE were searched for articles published in English since the 1989 NIH Development Consensus Conference on the Oral Complications of Cancer Therapies until 2008 inclusive. For each article, two independent reviewers extracted information regarding study design, study population, interventions, outcome measures, results, and conclusions. Seventy-two interventional studies met the inclusion criteria. In addition, 49 intensity-modulated radiation therapy (IMRT) studies were included as a management strategy aiming for less salivary gland damage. Management guideline recommendations were drawn up for IMRT, amifostine, muscarinic agonist stimulation, oral mucosal lubricants, acupuncture, and submandibular gland transfer. There is evidence that salivary gland hypofunction and xerostomia induced by cancer therapies can be prevented or symptoms be minimized to some degree, depending on the type of cancer treatment. Management guideline recommendations are provided for IMRT, amifostine, muscarinic agonist stimulation, oral mucosal lubricants, acupuncture, and submandibular gland transfer. Fields of sparse literature identified included effects of gustatory and masticatory stimulation, specific oral mucosal lubricant formulas, submandibular gland transfer, acupuncture, hyperbaric oxygen treatment, management strategies in pediatric cancer populations, and the economic consequences of salivary gland hypofunction and xerostomia.

引用

页码：1061 / 1079

页数：19

共 154 条

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