Synthesis and drug release behavior of poly (trimethylene carbonate)-poly (ethylene glycol)-poly (trimethylene carbonate) nanoparticles

被引：95

作者：

Zhang, Y ^{[1
]}

Zhuo, RX ^{[1
]}

机构：

[1] Wuhan Univ, Dept Chem, Key Lab Biomed Polymers, Minist Educ, Wuhan 430072, Peoples R China

来源：

BIOMATERIALS | 2005年 / 26卷 / 14期

基金：

中国国家自然科学基金;

关键词：

amphiphilic triblock copolymers; poly (ethylene glycol); poly (trimethylene carbonate); nanoparticles; methotrexate;

D O I：

10.1016/j.biomaterials.2004.06.004

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

ABA-type triblock copolymers poly (trimethylene carbonate)-poly (ethylene glycol)-poly (trimethylene carbonate) were synthesized by ring-opening polymerization of trimethylene carbonate initiated by dihydroxyl poly (ethylene glycol). The critical micelle concentration of amphiphilic triblock copolymers in aqueous solution was determined by fluorescence spectroscopy using 9-chloromethyl anthracene as fluorescence probe. Core-shell-type nanoparticles were prepared by the dialysis technique. Transmission electron microscopy images showed that these nanoparticles were regularly spherical in shape. Micelle size determined by, dynamic light scattering is 50-160 nm. Anticancer drug methotrexate (MTX) as model drug was loaded in the polymeric nanoparticks. X-ray powder diffraction spectra showed that model drugs were molecularly dispersed in the core. In vitro release behavior of MTX was investigated. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2089 / 2094

页数：6

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