Predictors of lymph node metastases in patients with malignant adenomatous polyps of the colon

被引：0

作者：

Artinyan, Avo ^{[1
,2
,7
]}

Wai, Christina ^{[6
]}

Zhu, Ruoyan ^{[3
]}

Sutanto, Christine ^{[3
]}

Sargsyan, Roman ^{[5
]}

Kasheri, Eli

Oka, Kimberly ^{[3
]}

Cohen, Jason ^{[3
,4
]}

Nasseri, Yosef ^{[3
,4
]}

机构：

[1] Acad Surg Associates, Los Angeles, CA USA

[2] Adventist Hlth Glendale, Glendale, CA USA

[3] Surg Grp Angeles, Los Angeles, CA USA

[4] Cedars Sinai Med Ctr, Los Angeles, CA USA

[5] Yerevan State Med Univ, Yerevan, Armenia

[6] Univ Hawaii, JABSOM, Honolulu, HI USA

[7] Acad Surg Associates, 1505 Wilson Ter,Ste 150, Glendale, CA 91206 USA

来源：

AMERICAN JOURNAL OF SURGERY | 2022年 / 223卷 / 04期

关键词：

Malignant polyp; Lymph node disease; Risk factors; Colon resection; INVASIVE COLORECTAL-CANCER; RISK; MANAGEMENT;

D O I：

10.1016/j.amjsurg.2021.07.003

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background: We sought to describe predictors of lymph node positivity in patients with malignant colon polyps to identify low risk patients who may potentially avoid radical surgery.Design: The National Cancer Database (2010-2015) was queried for all patients with malignant colonic polyps who underwent formal colonic resection. Univariate and multivariate methods were used to determine independent predictors of lymph node metastasis. Results: 14,663 patients were identified. Lymph node disease was present in 9% of patients. High-grade disease, LVI, PNI, younger age, and left sided location were univariate predictors of lymph node disease. High-grade disease (OR 1.84), left sided location (OR 1.31), LVI (OR 5.79), and PNI (OR 1.70) were independent predictors, while elderly age (OR 0.64) was protective (all p-values <0.001). Elderly patients with low grade disease of the right/transverse colon without LVI/PNI had a 4.4% risk of lymph node disease. High grade, left-sided tumors with LVI, non-elderly age, had a 30% risk. Conclusion: Non-elderly age, left-sided location, LVI, PNI and high-grade histology are independent predictors of lymph node metastasis in malignant colonic polyps.(c) 2021 Elsevier Inc. All rights reserved.

引用

页码：753 / 758

页数：6

共 16 条

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