Gastrin: An Acid-Releasing, Proliferative and Immunomodulatory Peptide?

被引：13

作者：

Calatayud, Sara ^{[1
]}

Alvarez, Angeles

Victor, Victor M.

机构：

[1] Univ Valencia, Dept Farmacol, Fac Med, Valencia 46010, Spain

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2010年 / 10卷 / 01期

关键词：

Gastrin; inflammation; immunomodulation; CCK-2; receptors; CCK-2 receptor antagonists; CHOLECYSTOKININ-B/GASTRIN RECEPTOR; HELICOBACTER-PYLORI INFECTION; ENDOTHELIAL CELL-INTERACTIONS; GENERALIZED ANXIETY DISORDER; PLACEBO-CONTROLLED TRIAL; CCK-B ANTAGONIST; IN-VIVO; PANIC DISORDER; DEFICIENT MICE; GROWTH-FACTOR;

D O I：

10.2174/138955710791112532

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Gastrin release is affected by gastric inflammatory conditions. Antral G cells respond to inflammatory mediators by increasing gastrin secretion. Accumulating experimental evidence suggests that gastrin exerts immunomodulatory and proinflammatory effects. Gastrin could be a contributing factor to these pathologies, which may constitute a new justification for pharmacological blockade of gastrin action.

引用

页码：8 / 19

页数：12

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