RAF1-activated MEK1 is found on the Golgi apparatus in late prophase and is required for Golgi complex fragmentation in mitosis

被引：56

作者：

Colanzi, A ^{[1
]}

Sutterlin, C ^{[1
]}

Malhotra, V ^{[1
]}

机构：

[1] Univ Calif San Diego, Cell & Dev Biol Dept, La Jolla, CA 92093 USA

来源：

JOURNAL OF CELL BIOLOGY | 2003年 / 161卷 / 01期

关键词：

mitogen-activated protein kinase kinase 1; cell cycle; organelle inheritance; RKIP; phosphorylation;

D O I：

10.1083/jcb.200208099

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Amitotically activated mitogen-activated protein kinase 1 (MEK1) fragments the pericentriolar Golgi stacks in mammalian cells. We show that activated MEK1 is found on the Golgi apparatus in late prophase. The fragmented and dispersed Golgi membranes in prometaphase and later stages of mitosis do not contain activated MEK1. MEK1-dependent Golgi complex fragmentation is through activation by RAF1 and not MEK1 kinase 1. We propose that a RAF1-dependent activation of MEK1 and its presence on the Golgi apparatus in late prophase is required for Golgi complex fragmentation.

引用

页码：27 / 32

页数：6

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