Extracellular vesicles for the treatment of central nervous system diseases

被引：56

作者：

Gratpain, Viridiane ^{[1
]}

Mwema, Ariane ^{[1
,2
]}

Labrak, Yasmine ^{[1
,2
]}

Muccioli, Giulio G. ^{[2
]}

van Pesch, Vincent ^{[3
,4
]}

des Rieux, Anne ^{[1
]}

机构：

[1] Catholic Univ Louvain, Louvain Drug Res Inst, Adv Drug Delivery & Biomat, UCLouvain, B-1200 Brussels, Belgium

[2] Catholic Univ Louvain, Louvain Drug Res Inst, Bioanal & Pharmacol Bioact Lipids, UCLouvain, B-1200 Brussels, Belgium

[3] Catholic Univ Louvain, Inst Neurosci, Neurochem Unit, UCLouvain, B-1200 Brussels, Belgium

[4] Clin Univ St Luc, B-1200 Brussels, Belgium

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2021年 / 174卷 / 174期

关键词：

miRNA; Nose to brain; Glioblastoma; Neurodegeneration; Neuroinflammation; Surface modification; Nanocarriers; Drug Delivery; Multiple Sclerosis; BLOOD-BRAIN-BARRIER; MESENCHYMAL STROMAL CELLS; CONVECTION-ENHANCED DELIVERY; DRUG-DELIVERY; ALPHA-SYNUCLEIN; IN-VITRO; PARKINSONS-DISEASE; ENDOTHELIAL MICROPARTICLES; ALZHEIMER-DISEASE; MEDIATED TRANSFER;

D O I：

10.1016/j.addr.2021.05.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The interest in extracellular vesicles (EVs) increased during the last decade. It is now established that these vesicles play a role in the pathogenesis of central nervous system diseases (CNS), which explains why they are studied as biomarkers in these pathologies. On the other hand, EVs can also present ther-apeutic properties, often similar to their parent cells, as observed with mesenchymal stem cell-derived EVs. They can then be used as therapeutics, alone or combined with a bioactive molecule, for the treat-ment of CNS diseases, as they can cross the blood-brain barrier more easily than synthetic nanomedici-nes and are less immunogenic. A few clinical trials are currently on-going but there are still challenges to overcome for further clinical translation such as the scale-up of the production, the lack of standardiza-tion for isolation and characterization methods and the low encapsulation efficiency. (c) 2021 Elsevier B.V. All rights reserved.

引用

页码：535 / 552

页数：18

共 184 条

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