An expedient reductive method for conversion of ketoximes to the corresponding carbonyl compounds

被引：16
|
作者：
Majireck, Max M. [1 ]
Witek, Jason A. [1 ]
Weinreb, Steven M. [1 ]
机构：
[1] Penn State Univ, Dept Chem, University Pk, PA 16802 USA
来源：
TETRAHEDRON LETTERS | 2010年 / 51卷 / 27期
基金：
美国国家卫生研究院;
关键词：
Oximes; Reduction; VINYLNITROSO COMPOUNDS; OXIMES; REGENERATION; DEOXIMATION; KETONES;
D O I：
10.1016/j.tetlet.2010.04.131
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A wide array of readily prepared pivalates of ketoximes can be converted to the corresponding ketones in good yields by treatment with iron powder in THF containing catalytic amounts of both trimethylsilyl chloride and glacial acetic acid at room temperature for 30 min, followed by a brief aqueous workup. (C) 2010 Elsevier Ltd. All rights reserved.
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页码：3555 / 3557
页数：3
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