circ_0001730 promotes proliferation and invasion via the miR-326/Wnt7B axis in glioma cells

被引：48
|
作者：
Lu, Yaoyong [1 ]
Deng, Xubin [2 ]
Xiao, Guanghui [3 ]
Zheng, Xin [4 ]
Ma, Lei [2 ]
Huang, Wendong [5 ]
机构：
[1] Gaozhou Peoples Hosp, Sect 3, Dept Oncol, Gaozhou, Guangdong, Peoples R China
[2] Guangzhou Med Univ, Affiliated Canc Hosp & Inst, Dept Internal Med, Guangzhou, Guangdong, Peoples R China
[3] Fox Chase Canc Ctr, Dept Canc Biol Program, Canc Biol Program, Philadelphia, PA 215 USA
[4] Southern Med Univ, Yanling Hosp, Dept Internal Med, Guangzhou, Guangdong, Peoples R China
[5] Maoming Peoples Hosp, Dept Pharm, Maoming, Guangdong, Peoples R China
来源：
EPIGENOMICS | 2019年 / 11卷 / 11期
关键词：
beta-catenin; circRNAs; epithelial to mesenchymal transition; glioblastoma; miR-326; Wnt7B; CIRCULAR RNA; BIOLOGICAL BEHAVIORS; CANCER; EXPRESSION; WNT7B; ADULTS; BRAIN; MIR-7;
D O I：
10.2217/epi-2019-0121
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Aim: To study the role of circRNA (circ_0001730) in glioblastoma. Materials & methods: The interaction between circ 0001730 and miR-326 was confirmed by FISH, RNA pull down, RNA-binding protein immunoprecipitation and luciferase reporter assays. Cell proliferation and growth were determined by MTT, EdU and colony formation assays. Cell migration was assessed by the Boyden assay. Results: The levels of circ_0001730 were elevated in glioblastoma cell lines and tissues. circ_0001730 downregulation suppressed migration and proliferation in glioblastoma cells. SP1 bounds to the promoter of circ 0001730 host gene EPHB4 thereby increasing the expression of circ_0001730. circ_0001730 activated the Wnt/beta-catenin pathway via the miR-326/Wnt7B axis. Conclusion: circ_000173 promoted growth and invasion in glioblastoma cells via the miR-326/Wnt7B axis.
引用
收藏
页码：1335 / 1353
页数：19
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