SYNTHESIS AND ANTIBACTERIAL AND IMMUNOBIOLOGICAL ACTIVITY OF ETHYL-1-(4-AMINOSULFONYLPHENYL)-5ARYL-3-HYDROXY-2-OXO-3-PYRROLINE-4-CARBOXYLATES

被引：2

作者：

Gein, V. L. ^{[1
]}

Bobrovskaya, O. V. ^{[1
]}

Odegova, T. F. ^{[1
]}

Krylova, I. V. ^{[2
]}

Gein, O. N. ^{[1
]}

Sopova, E. E. ^{[3
]}

Gein, S. V. ^{[3
]}

机构：

[1] RF Minist Hlth, Perm State Pharmaceut Acad, Ul Polevaya 2, Perm 614990, Russia

[2] Perm State Natl Res Univ, Perm 614990, Russia

[3] Perm State Med Acad, Perm 614000, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2016年 / 49卷 / 10期

关键词：

synthesis; ethyl-1-(4-aminosulfonylphenyl)-5-aryl-3-hydroxy-2-oxo-3-pyrroline-4-carboxylates; antibacterial and immunobiological activity;

D O I：

10.1007/s11094-016-1351-z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of ethyl-1-(4-aminosulfonylphenyl)-5-aryl-3-hydroxy-2-oxo-3-pyrroline-4-carboxylates were synthesized via a three-component reaction of sodium diethyloxalylacetate and a mixture of an aromatic aldehyde and 4-aminobenzenesulfonamide. The structures of the compounds were established using IR and PMR spectroscopy and mass spectrometry. The antibacterial and immunobiological activities of the synthesized compounds were studied.

引用

页码：677 / 679

页数：3

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