Stereoselective Total Synthesis of Bioactive Marine Natural Product Biselyngbyolide B

被引：50

作者：

Das, Sayantan ^{[1
]}

Paul, Debobrata ^{[1
]}

Goswami, Rajib Kumar ^{[1
]}

机构：

[1] Indian Assoc Cultivat Sci, Dept Organ Chem, Kolkata 700032, India

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 08期

关键词：

CYANOBACTERIUM LYNGBYA SP; FORMAL SYNTHESIS; ALLYLIC ALCOHOLS; ALDOL ADDITIONS; CONDENSATION; PALMEROLIDE; CONVERSION; MACROLIDE; ALDEHYDES; SULFONES;

D O I：

10.1021/acs.orglett.6b00713

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convergent strategy for the stereoselective total synthesis of biologically active marine natural product biselyngbyolide B has been developed. Key strategies of this synthesis include Jamison protocol of transhydroalumination/allylation for installation of C-18-C-23 olefin moiety and intramolecular Heck coupling for macrocyclization.

引用

页码：1908 / 1911

页数：4

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