Soft tissue sarcomas with non-EWS translocations: molecular genetic features and pathologic and clinical correlations

被引：26

作者：

Fisher, Cyril ^{[1
,2
]}

机构：

[1] Royal Marsden Hosp, London SW3 6JJ, England

[2] Royal Marsden NHS Fdn Trust, Dept Pathol, London, England

来源：

VIRCHOWS ARCHIV | 2010年 / 456卷 / 02期

关键词：

Translocation; Soft tissue sarcoma; Molecular genetics; GRADE FIBROMYXOID SARCOMA; INFLAMMATORY MYOFIBROBLASTIC TUMOR; GIANT-CELL FIBROBLASTOMA; SSX FUSION TYPE; DIFFERENTIATED SYNOVIAL SARCOMA; POLYMERASE-CHAIN-REACTION; CONGENITAL-INFANTILE FIBROSARCOMA; ANAPLASTIC LYMPHOMA KINASE; GROWTH-FACTOR-B; COMPARATIVE GENOMIC HYBRIDIZATION;

D O I：

10.1007/s00428-009-0776-0

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Many soft tissue sarcoma subtypes have consistent chromosomal translocations with novel fusion genes, which result in disordered cellular function. The microscopic appearances, immunophenotype and behaviour of such tumours relate to the genetic events to a variable extent. This paper reviews the molecular pathology and related morphological and clinical features of sarcomas with non-EWS translocations. These include synovial sarcoma, alveolar rhabdomyosarcoma, alveolar soft part sarcoma, dermatofibrosarcoma protuberans, low-grade fibromyxoid sarcoma, infantile fibrosarcoma and inflammatory myofibroblastic tumour.

引用

页码：153 / 166

页数：14

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