Sonogashira coupling reaction with diminished homocoupling

被引：271
作者：
Elangovan, A [1 ]
Wang, YH [1 ]
Ho, TI [1 ]
机构：
[1] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan
来源：
ORGANIC LETTERS | 2003年 / 5卷 / 11期
关键词：
D O I：
10.1021/ol034320+
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The side product from homocoupling reaction of two terminal acetylenes in the Sonogashira reaction can be reduced to about 2% using an atmosphere of hydrogen gas diluted with nitrogen or argon. Terminal arylethynes, diarylethynes, and a few new arylpyridylethynes with donor substituents have been synthesized in very good yields. Comparative control experiments suggest that the homocoupling yield is determined by concentration of both catalyst and oxygen.
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页码：1841 / 1844
页数：4
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