Cisplatin Augments FAS-mediated Apoptosis through Lipid Rafts

被引：0

作者：

Huang, Cheng-Ri ^{[1
]}

Jin, Zhe-Xiong ^{[1
]}

Dong, Lingli ^{[1
,3
]}

Tong, Xiao-Peng ^{[1
]}

Yue, Sun ^{[1
]}

Kawanami, Takafumi ^{[1
]}

Sawaki, Toshioki ^{[1
]}

Sakai, Tomoyuki ^{[1
]}

Miki, Miyuki ^{[1
]}

Iwaoi, Haruka ^{[1
]}

Nakajima, Akio ^{[1
]}

Masaki, Yasufumi ^{[1
]}

Fukushima, Yoshihiko ^{[1
]}

Tanaka, Masao ^{[1
]}

Fujita, Yoshimasa ^{[1
]}

Nakajima, Hideo ^{[2
]}

Okazaki, Toshiro ^{[4
]}

Umehara, Hisanori ^{[1
]}

机构：

[1] Kanazawa Med Univ, Dept Hematol & Immunol, Uchinada, Ishikawa 9200293, Japan

[2] Kanazawa Med Univ, Dept Med Oncol, Uchinada, Ishikawa 9200293, Japan

[3] Huazhong Univ Sci & Technol, Tongji Hosp, Dept Rheumatol, Wuhan 430030, Hubei, Peoples R China

[4] Tottori Univ, Fac Med, Tottori 6838504, Japan

来源：

ANTICANCER RESEARCH | 2010年 / 30卷 / 06期

关键词：

Cisplatin; FAS; apoptosis; sphingomyelin; lipid rafts; TYROSINE KINASE P72(SYK); T-CELLS; ACTIVATION; CD95; SPHINGOMYELIN; CERAMIDE; REDISTRIBUTION; CYTOTOXICITY; INHIBITION; PROTEINS;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cisplatin is widely and effectively used for the treatment of various types of cancer. However, its biochemical mechanisms are still unelucidated. Previously, we reported that membrane sphingomyelin (SM) was important for FAS-mediated apoptosis through lipid raft function. In this study, we strikingly show that cisplatin combined with CH11 (anti-FAS antibody, IgM) was able to induce marked apoptosis in SM synthase-restored WR/Fas-SMS1 cells, but not in SM synthase-deficient WR/FAS-SM(-) cells. In addition, we demonstrated that membrane SM played an important role in cisplatin/CH11-induced apoptosis through the classical caspase-dependent pathway, mainly by enhancing the formation of FAS-associated signaling complexes.

引用

页码：2065 / 2071

页数：7

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