Salivary biomarkers indicate obstructive sleep apnea patients with cardiovascular diseases

被引：29

作者：

Zheng, Hui ^{[1
]}

Li, Ruoxuan ^{[2
]}

Zhang, Jieni ^{[1
]}

Zhou, Shaonan ^{[1
]}

Ma, Qingwei ^{[3
]}

Zhou, Yanheng ^{[1
]}

Chen, Feng ^{[4
]}

Lin, Jiuxiang ^{[1
]}

机构：

[1] Peking Univ, Sch & Hosp Stomatol, Dept Orthodont, Beijing 100081, Peoples R China

[2] Capital Med Univ, Beijing Anzhen Hosp, Dept Stomatol, Beijing 100029, Peoples R China

[3] BioyongTech, Beijing 100085, Peoples R China

[4] Peking Univ, Sch & Hosp Stomatol, Cent Lab, Beijing 100081, Peoples R China

来源：

SCIENTIFIC REPORTS | 2014年 / 4卷

基金：

中国国家自然科学基金;

关键词：

FETUIN-A; PROTEOMICS; DISCOVERY; TOOL;

D O I：

10.1038/srep07046

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Although obstructive sleep apnea (OSA) patients are at high risk of developing cardiovascular disease (CVD), only a small proportion is currently diagnosed. To explore and identify the differentially expressed proteins/peptides of OSA patients with CVDs, a mass spectrometry-based salivary analysis was performed. In our study, eleven peaks were observed differentially expressed in saliva from the non-CVD and CVD groups. Five masses mass peaks (1594.1, 1673.7, 1196.6, 1290.5, and 1447.0 Da) showed an upregulated trend in the CVD group, whereas six mass peaks (3038.6, 2164.3, 2301.4, 3195.0, 2628.4, and 1721.9 Da) were downregulated in the CVD group. In addition, the alpha-2-HS-glycoprotein (AHSG) levels in saliva were verified to be decreased in CVD group compared to non-CVD group. Analysis of the salivary peptidome provides a promising approach to screening for novel biomarkers before further identification, and may contribute to early diagnosis of CVD patients with OSA.

引用

页数：7

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