CYP2D6*10 alleles do not determine plasma fluvoxamine concentration/dose ratio in Japanese subjects

被引:24
作者
Ohara, K [1 ]
Tanabu, S [1 ]
Ishibashi, K [1 ]
Ikemoto, K [1 ]
Yoshida, K [1 ]
Shibuya, H [1 ]
机构
[1] Natl Minami Hanamaki Hosp, Clin Res Inst, Hanamaki 0250033, Japan
关键词
fluvoxamine; CYP2D6; *10 allele;
D O I
10.1007/s00228-002-0529-3
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Objective: The purpose of the present study was to investigate whether plasma fluvoxamine (FV) concentration is associated with CYP2D6*10 allele polymorphisms. Methods: Subjects were 46 Japanese patients (21 males) carrying neither *3, *4 nor *5 alleles and treated orally using FV. Venous blood was obtained from each patient for determination of FV concentration/dose (C/D) ratio (plasma concentration of FV divided by daily dose of FV per body weight) and CYP2136 genotyping. Results: No significant differences in FV C/D ratio were found between subjects with no (n=13), one (n=18) or two (n=15) *10 alleles. Conclusion: Our results indicate that CYP2D6*10 genotypes do not exert significant effects on FV C/D ratio. As CYP2136 genotypes differ with ethnic background, further studies should be conducted in different populations.
引用
收藏
页码:659 / 661
页数:3
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