Protective effects of rutaecarpine in cardiac anaphylactic injury is mediated by CGRP

被引：35

作者：

Yi, HH ^{[1
]}

Rang, WQ ^{[1
]}

Deng, PY ^{[1
]}

Hu, CP ^{[1
]}

Liu, GZ ^{[1
]}

Tan, GS ^{[1
]}

Xu, KP ^{[1
]}

Li, YJ ^{[1
]}

机构：

[1] Cent S Univ, Sch Pharmaceut Sci, Dept Pharmacol, Changsha 410078, Hunan, Peoples R China

来源：

PLANTA MEDICA | 2004年 / 70卷 / 12期

关键词：

Cardiac anaphylaxis; calcitonin gene-related peptide (CGRP); rutaecarpine; tumor necrosis factor-alpha (TNF-alpha); guinea-pig;

D O I：

10.1055/s-2004-835840

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Previous investigations have indicated that rutaecarpine activates the vanilloid receptor to evoke calcitonin gene-related peptide (CGRP) release. CGRP has been shown to alleviate cardiac anaphylactic injury. In the present study, the effect of rutaecarpine on cardiac anaphylaxis was examined. Challenge of presensitized guinea-pig hearts with a specific antigen caused marked decreases in coronary flow (CF), left ventricular pressure (LVP) and its derivatives (+/- dp/dt(max)), an increase in heart rate, and prolongation of the P-R interval. Rutaecarpine (0.3 or 1 muM) markedly increased the content of calcitonin gene-related peptide (CGRP) in the coronary effluent and decreased the content of tumor necrosis factor-alpha (TNF-alpha) in myocardial tissues concomitantly with a significant improvement of cardiac function and alleviation of the extension of the P-R interval. Rutaecarpine at the concentration of 1 muM also inhibited the sinus tachycardia. The protective effects of rutaecarpine on cardiac anaphylaxis were abolished by CGRP(8-37), a selective CGRP receptor antagonist. These results suggest that the Protective effects of rutaecarpine on cardiac anaphylactic injury are related to inhibition of TNF-a production by stimulation of CGRP release.

引用

页码：1135 / 1139

页数：5

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