PrPSc in salivary glands of scrapie-affected sheep

被引：50

作者：

Vascellari, Marta

Nonno, Romolo

Mutinelli, Franco

Bigolaro, Michela

Di Bari, Michele Angelo

Melchiotti, Erica

Marcon, Stefano

D'Agostino, Claudia

Vaccari, Gabriele

Conte, Michela

De Grossi, Luigi

Rosone, Francesca

Giordani, Francesco

AgriMi, Umberto

机构：

[1] Ist Zooprofilatt Sperimentale Venezie, Dept Histopathol, I-35020 Legnaro, PD, Italy

[2] Ist Super Sanita, Dept Food Safety & Anim Hlth, I-00161 Rome, Italy

[3] Ist Zooprofilatt Sperimentale Reg Lazio & Toscana, I-01100 Viterbo, Italy

来源：

JOURNAL OF VIROLOGY | 2007年 / 81卷 / 09期

关键词：

D O I：

10.1128/JVI.02148-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The salivary glands of scrapie-affected sheep and healthy controls were investigated for the presence of the pathological prion protein (PrPSc). PrPs' was detected in major (parotid and mandibular) and minor (buccal, labial, and palatine) salivary glands of naturally and experimentally infected sheep. Using Western blotting, the PrPs' concentration in glands was estimated to be 0.02 to 0.005% of that in brain. Immunohistochemistry revealed intracellular depositions of PrPSc in ductal and acinar epithelia and occasional labeling in the lumina of salivary ducts. The presence of PrPSc in salivary glands highlights the possible role of saliva in the horizontal transmission of scrapie.

引用

页码：4872 / 4876

页数：5

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