Metallo-β-lactamase-producing imipenem-resistant Pseudomonas aeruginosa clinical isolates in a university teaching hospital in Malaysia: detection of IMP-7 and first identification of IMP-4, VIM-2, and VIM-11

被引：15

作者：

Khosravi, Yalda ^{[1
]}

Tay, Sun Tee ^{[1
]}

Vadivelu, Jamuna ^{[1
]}

机构：

[1] Univ Malaya, Fac Med, Dept Med Microbiol, Kuala Lumpur 50603, Malaysia

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2010年 / 67卷 / 03期

关键词：

Metallo-beta-lactamase (MBL) genes; Pseudomonas aeruginosa; Imipenem resistance; bla(IMP); bla(VIM); Carbapenems; GENES; SPP;

D O I：

10.1016/j.diagmicrobio.2010.02.010

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Ninety (n = 90) imipenem-resistant Pseudomonas aeruginosa (IRPA) clinical isolates collected randomly during 2005 to 2008 from University Malaya Medical Center were assessed for the presence of different variants of metallo-beta-lactamase (MBL) genes. Polymerase chain reaction (PCR) assay detected 32 (n = 32) MBL gene PCR-positive isolates with the presence of bla(IMP) gene in 14 (n = 14) and bla(VIM) in 18 (n = 18) isolates. Four allelic variants, bla(IMP-7) (12 isolates), bla(IMP-4) (2 isolates), bla(VIM-2) (17 isolates), and bla(VIM-11) (1 isolate), of MBL genes were identified. This study is the first report of detection of bla(IMP-4), bla(VIM-2), and bla(VIM-11) MBL genes from IRPA clinical isolates in Malaysia. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：294 / 296

页数：3

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