The North American Neuroendocrine Tumor Society Consensus Guidelines for Surveillance and Medical Management of Midgut Neuroendocrine Tumors

被引：231

作者：

Strosberg, Jonathan R. ^{[1
]}

Halfdanarson, Thorvardur R. ^{[2
]}

Bellizzi, Andrew M. ^{[3
]}

Chan, Jennifer A. ^{[4
]}

Dillon, Joseph S. ^{[5
]}

Heaney, Anthony P. ^{[6
,7
]}

Kunz, Pamela L. ^{[8
]}

O'Dorisio, Thomas M. ^{[5
]}

Salem, Riad ^{[9
]}

Segelov, Eva ^{[10
,11
]}

Howe, James R. ^{[12
]}

Pommier, Rodney F. ^{[13
]}

Brendtro, Kari ^{[14
]}

Bashir, Mohammad A. ^{[15
]}

Singh, Simron ^{[16
]}

Soulen, Michael C. ^{[17
]}

Tang, Laura ^{[18
]}

Zacks, Jerome S. ^{[19
]}

Yao, James C. ^{[20
]}

Bergsland, Emily K. ^{[21
]}

机构：

[1] H Lee Moffitt Canc Ctr & Res Inst, Dept GI Oncol, Tampa, FL USA

[2] Mayo Clin, Div Med Oncol, Rochester, MN USA

[3] Univ Iowa, Dept Pathol, Iowa City, IA 52242 USA

[4] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[5] Univ Iowa, Dept Med, Iowa City, IA 52242 USA

[6] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA

[7] Univ Calif Los Angeles, Dept Neurosurg, Los Angeles, CA USA

[8] Stanford Univ, Sch Med, Dept Med, Div Oncol, Stanford, CA 94305 USA

[9] Northwestern Univ, Dept Radiol, Chicago, IL 60611 USA

[10] Monash Univ, Dept Oncol, Melbourne, Vic, Australia

[11] Monash Hlth, Melbourne, Vic, Australia

[12] Univ Iowa, Dept Surg, Carver Coll Med, Iowa City, IA 52242 USA

[13] Oregon Hlth & Sci Univ, Portland, OR USA

[14] North Amer Neuroendocrine Tumor Soc, Portland, OR USA

[15] Univ Iowa, Dept Surg, Carver Coll Med, Div Cardiothorac Surg, Iowa City, IA 52242 USA

[16] Sunnybrook Med Ctr, Toronto, ON, Canada

[17] Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA

[18] Mem Sloan Kettering Univ, New York, NY USA

[19] Mt Sinai Hosp, Div Cardiol, New York, NY 10029 USA

[20] MD Anderson Canc Ctr, Dept Gastrointestinal Med Oncol, Houston, TX USA

[21] Univ Calif San Francisco, Dept Med, San Francisco, CA USA

来源：

PANCREAS | 2017年 / 46卷 / 06期

关键词：

NANETS; medical management; neuroendocrine tumor; midgut NETs; MALIGNANT CARCINOID-SYNDROME; INTERFERON-ALPHA; CHROMOGRANIN-A; GASTROENTEROPANCREATIC TUMORS; DOUBLE-BLIND; OCTREOTIDE; LANREOTIDE; SURVIVAL; MULTICENTER; EVEROLIMUS;

D O I：

10.1097/MPA.0000000000000850

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

There have been significant developments in diagnostic and therapeutic options for patients with neuroendocrine tumors (NETs). Key phase 3 studies include the CLARINET trial, which evaluated lanreotide in patients with nonfunctioning enteropancreatic NETs; the RADIANT-2 and RADIANT-4 studies, which evaluated everolimus in functioning and nonfunctioning NETs of the gastrointestinal tract and lungs; the TELESTAR study, which evaluated telotristat ethyl in patientswith refractory carcinoid syndrome; and the NETTER-1 trial, which evaluated Lu-177-DOTATATE in NETs of the small intestine and proximal colon (midgut). Based on these and other advances, the North American Neuroendocrine Tumor Society convened a multidisciplinary panel of experts with the goal of updating consensus-based guidelines for evaluation and treatment of midgut NETs. The medical aspects of these guidelines (focusing on systemic treatment, nonsurgical liver-directed therapy, and postoperative surveillance) are summarized in this article. Surgical guidelines are described in a companion article.

引用

页码：707 / 714

页数：8

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