Subthalamic Nucleus Stimulation Affects Theory of Mind Network: A PET Study in Parkinson's Disease

被引：52

作者：

Peron, Julie ^{[1
,2
]}

Le Jeune, Florence ^{[2
,3
]}

Haegelen, Claire ^{[2
,4
]}

Dondaine, Thibaut ^{[1
,2
,5
]}

Drapier, Dominique ^{[2
,5
]}

Sauleau, Paul ^{[2
,6
]}

Reymann, Jean-Michel ^{[2
,7
]}

Drapier, Sophie ^{[1
,2
]}

Rouaud, Tiphaine ^{[1
,2
]}

Millet, Bruno ^{[2
,5
]}

Verin, Marc ^{[1
,2
]}

机构：

[1] CHU Rennes, Hop Pontchaillou, Neurol Clin, Rennes, France

[2] Univ Rennes 1, Hop Pontchaillou, CHU Rennes, Unite Rech Univ EM Behav & Basal Ganglia 425, Rennes, France

[3] Ctr Anticanc Eugene Marquis Rennes, Nucl Med Serv, Rennes, France

[4] CHU Rennes, Hop Pontchaillou, Serv Neurochirurg, Rennes, France

[5] Ctr Hosp Guillaume Regnier Rennes, Serv Hosp Univ Psychiat Adulte, Rennes, France

[6] CHU Rennes, Hop Pontchaillou, Serv Explorat Fonct, Rennes, France

[7] CHU Rennes, Hop Pontchaillou, Ctr Invest Clin, Rennes, France

来源：

PLOS ONE | 2010年 / 5卷 / 03期

关键词：

DEEP BRAIN-STIMULATION; VARIANT FRONTOTEMPORAL DEMENTIA; FRONTAL VARIANT; BASAL GANGLIA; FDG-PET; EXPRESSION RECOGNITION; EMOTION RECOGNITION; ALZHEIMERS-DISEASE; SOCIAL COGNITION; SCHIZOPHRENIA;

D O I：

10.1371/journal.pone.0009919

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background: There appears to be an overlap between the limbic system, which is modulated by subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson's disease (PD), and the brain network that mediates theory of mind (ToM). Accordingly, the aim of the present study was to investigate the effects of STN DBS on ToM of PD patients and to correlate ToM modifications with changes in glucose metabolism. Methodology/Principal Findings: To this end, we conducted (18)FDG-PET scans in 13 PD patients in pre- and post-STN DBS conditions and correlated changes in their glucose metabolism with modified performances on the Eyes test, a visual ToM task requiring them to describe thoughts or feelings conveyed by photographs of the eye region. Postoperative PD performances on this emotion recognition task were significantly worse than either preoperative PD performances or those of healthy controls (HC), whereas there was no significant difference between preoperative PD and HC. Conversely, PD patients in the postoperative condition performed within the normal range on the gender attribution task included in the Eyes test. As far as the metabolic results are concerned, there were correlations between decreased cerebral glucose metabolism and impaired ToM in several cortical areas: the bilateral cingulate gyrus (BA 31), right middle frontal gyrus (BA 8, 9 and 10), left middle frontal gyrus (BA 6), temporal lobe (fusiform gyrus, BA 20), bilateral parietal lobe (right BA 3 and right and left BA 7) and bilateral occipital lobe (BA 19). There were also correlations between increased cerebral glucose metabolism and impaired ToM in the left superior temporal gyrus (BA 22), left inferior frontal gyrus (BA 13 and BA 47) and right inferior frontal gyrus (BA 47). All these structures overlap with the brain network that mediates ToM. Conclusion/Significance: These results seem to confirm that STN DBS hinders the ability to infer the mental states of others and modulates a distributed network known to subtend ToM.

引用

页数：9

共 68 条

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