In Vitro Evaluation of Paclitaxel Loaded Magnetic Nanoparticles for Breast Cancer Therapy

被引：0
作者：
Ursachi, V. C. [1 ,2 ]
Mihai, C. T. [3 ]
Nastuta, A. [1 ]
Dimitriu, C. D. [4 ]
Verestiuc, L. [1 ]
Balan, V [1 ]
机构：
[1] Grigore T Popa Univ Med & Pharm, Fac Med Bioengn, 9-13 Kogalniceanu St, Iasi 700454, Romania
[2] Petra Poni Inst Macromol Chem, Nat Polymers Bioact & Biocompatible Mat Lab, Iasi 700487, Romania
[3] Grigore T Popa Univ Med & Pharm, Adv Ctr Res Dev Expt Med, Iasi, Romania
[4] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Morphol & Funct Sci, Iasi, Romania
来源：
2021 INTERNATIONAL CONFERENCE ON E-HEALTH AND BIOENGINEERING (EHB 2021), 9TH EDITION | 2021年
关键词：
magnetic nanoparticles; breast cancer; Paclitaxel; biotinylated N-palmitoyl chitosan; IRON-OXIDE NANOPARTICLES; BIOTIN;
D O I：
10.1109/EHB52898.2021.9657671
中图分类号：
R19 [保健组织与事业（卫生事业管理）];
学科分类号：
摘要：
This paper presents in vitro evaluation of several characteristics of Paclitaxel loaded magnetic nanoparticles based on iron oxide nanosferes and biotinylated N-palmitoyl chitosan for potential applications as drug delivery system in breast cancer therapy. Obtained magnetic nanoparticles were dispersible in glucose solution (10 %), induced apoptosis in MDA-MB-231 cells and they did not determine notable modification of the coagulation parameter (time of partially activated thromboplastin-APTT) after the contact with blood. In the presence of a magnetic field, the nanoparticles aligned in the direction of the field lines.
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页数：4
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