Pharmacologic Management of Portal Hypertension

被引：24
作者：
Bunchorntavakul, Chalermrat [1 ,2 ]
Reddy, K. Rajender [2 ]
机构：
[1] Rangsit Univ, Rajavithi Hosp, Div Gastroenterol & Hepatol, Dept Med, Rajavithi Rd, Bangkok 10400, Thailand
[2] Univ Penn, Dept Med, Div Gastroenterol & Hepatol, 2 Dulles,3400 Spruce St, Philadelphia, PA 19104 USA
来源：
CLINICS IN LIVER DISEASE | 2019年 / 23卷 / 04期
关键词：
Portal hypertension; Variceal hemorrhage; Terlipressin; Somatostatin; Propranolol; Carvedilol; VARICEAL BAND LIGATION; INTRAHEPATIC ENDOTHELIAL DYSFUNCTION; RANDOMIZED CONTROLLED-TRIAL; NONSELECTIVE BETA-BLOCKERS; TERLIPRESSIN PLUS ALBUMIN; AGONIST OBETICHOLIC ACID; CIRRHOTIC RAT LIVERS; HEPATORENAL-SYNDROME; DOUBLE-BLIND; SYSTEMIC HEMODYNAMICS;
D O I：
10.1016/j.cld.2019.06.004
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Terlipressin, somatostatin, or octreotide are recommended as pharmacologic treatment of acute variceal hemorrhage. Nonselective beta-blockers decrease the risk of variceal hemorrhage and hepatic decompensation, particularly in those 30% to 40% of patients with good hemodynamic response. Carvedilol, statins, and anticoagulants are promising agents in the management of portal hypertension. Recent advances in the pharmacologic treatment of portal hypertension have mainly focused on modifying an increased intrahepatic resistance through nitric oxide and/or modulation of vasoactive substances. Several novel pharmacologic agents for portal hypertension are being evaluated in humans.
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收藏
页码：713 / +
页数：25
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