Genetic variation of occult hepatitis B virus infection

被引：61

作者：

Zhu, Hui-Lan ^{[1
]}

Li, Xu ^{[1
]}

Li, Jun ^{[2
]}

Zhang, Zhen-Hua ^{[1
,2
]}

机构：

[1] Anhui Med Univ, Affiliated Hosp 1, Dept Infect Dis, 218 Jixi Rd, Hefei 230022, Anhui, Peoples R China

[2] Anhui Med Univ, Sch Pharm, Hefei 230022, Anhui, Peoples R China

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2016年 / 22卷 / 13期

基金：

高等学校博士学科点专项科研基金; 美国国家科学基金会;

关键词：

Hepatitis B virus; Occult; Variation; Hepatitis B surface antigen; AMINO-ACID SUBSTITUTIONS; BLOOD MONONUCLEAR-CELLS; SURFACE-ANTIGEN HBSAG; SMALL ENVELOPE PROTEIN; CHRONIC LIVER-DISEASE; HBV INFECTION; HEPATOCELLULAR-CARCINOMA; CLINICAL-IMPLICATIONS; FUNCTIONAL-ANALYSIS; C VIRUS;

D O I：

10.3748/wjg.v22.i13.3531

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Occult hepatitis B virus infection (OBI), characterized as the persistence of hepatitis B virus (HBV) surface antigen (HBsAg) seronegativity and low viral load in blood or liver, is a special form of HBV infection. OBI may be related mainly to mutations in the HBV genome, although the underlying mechanism of it remains to be clarified. Mutations especially within the immunodominant "alpha" determinant of S protein are "hot spots" that could contribute to the occurrence of OBI via affecting antigenicity and immunogenicity of HBsAg or replication and secretion of virion. Clinical reports account for a large proportion of previous studies on OBI, while functional analyses, especially those based on full-length HBV genome, are rare.

引用

页码：3531 / 3546

页数：16

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