The regulation of hematopoietic stem cell and progenitor mobilization by chemokine SDF-1

被引：106

作者：

Hattori, K ^{[1
]}

Heissig, B ^{[1
]}

Rafii, S ^{[1
]}

机构：

[1] Cornell Univ, Weill Med Coll, Div Hematol Oncol, New York, NY 10021 USA

来源：

LEUKEMIA & LYMPHOMA | 2003年 / 44卷 / 04期

关键词：

SDF-1; hematopoietic stem cell mobilization; chemokines; matrix metalloproteinase-1;

D O I：

10.1080/1042819021000037985

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The chemokine, stromal derived factor-1 (SDF1) has been shown to modulate the homing of stem cells to its site by mediating chemotaxis. We demontrated overexpression of SDF-1 induced mobilization of cells with stem cell potential (CFU-S, long-term reconstituting cells). Moreover, SDF-1 activated matrix metalloproteinase-9 induced in bone marrow (BM) cells, causing the release soluble Kit-ligand and permitting the transfer of hematopoietic stem cells (HSCs) from a quiescent to a proliferative niche. The role of SDF-1 in the process of HSC migration and the mechanism underlying this HSCs migration will be reviewed. These studies lay the foundation for using SDF-1 to induce mobilization of progenitor cells in a BM transplantation setting.

引用

页码：575 / 582

页数：8

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