Chemistry of pseudomonic acid .16. Aryl and heteroaryl ketone derivatives of monic acid

被引：6

作者：

Abson, A ^{[1
]}

Broom, NJP ^{[1
]}

Coates, PA ^{[1
]}

Elder, JS ^{[1
]}

Forrest, AK ^{[1
]}

Hannan, PCT ^{[1
]}

Hicks, AJ ^{[1
]}

OHanlon, PJ ^{[1
]}

Masson, ND ^{[1
]}

Pearson, ND ^{[1
]}

Pons, JE ^{[1
]}

Wilson, JM ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,BETCHWORTH RH3 7AJ,SURREY,ENGLAND

来源：

JOURNAL OF ANTIBIOTICS | 1996年 / 49卷 / 04期

关键词：

D O I：

10.7164/antibiotics.49.390

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The synthesis, antibacterial activities, murine pharmacokinetic and infection model data for a range of aryl and heteroaryl ketone derivatives of monic acid (2a) are reported. The best results were found for the 3-furyl and 2-methoxy thiazol-5-yl analogues.

引用

页码：390 / 394

页数：5

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