The macrophage: the intersection between HIV infection and atherosclerosis

被引：109
作者：
Crowe, Suzanne M. [1 ,2 ,3 ]
Westhorpe, Clare L. V. [1 ]
Mukhamedova, Nigora [5 ]
Jaworowski, Anthony [1 ,3 ,4 ]
Sviridov, Dmitri [5 ]
Bukrinsky, Michael [6 ]
机构：
[1] Macfarlane Burnet Inst Med Res & Publ Hlth, Ctr Virol, Melbourne, Vic 3004, Australia
[2] Alfred Hosp, Infect Dis Unit, Melbourne, Vic, Australia
[3] Monash Univ, Dept Med, Melbourne, Vic 3004, Australia
[4] Monash Univ, Dept Immunol, Melbourne, Vic 3004, Australia
[5] Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia
[6] George Washington Univ, Med Ctr, Dept Microbiol Immunol & Trop Med, Washington, DC 20037 USA
来源：
JOURNAL OF LEUKOCYTE BIOLOGY | 2010年 / 87卷 / 04期
关键词：
inflammation; monocyte migration; cholesterol; coronary heart disease; C-REACTIVE PROTEIN; PERIPHERAL-BLOOD MONOCYTES; IMMUNODEFICIENCY-VIRUS TYPE-1; CORONARY-HEART-DISEASE; REVERSE-TRANSCRIPTASE INHIBITORS; ACTIVE ANTIRETROVIRAL THERAPY; PREFERENTIALLY HARBORS HIV-1; ACUTE MYOCARDIAL-INFARCTION; TOLL-LIKE RECEPTORS; FC-GAMMA RECEPTORS;
D O I：
10.1189/jlb.0809580
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
HIV-infected individuals are at increased risk of coronary artery disease (CAD) with underlying mechanisms including chronic immune activation and inflammation secondary to HIV-induced microbial translocation and low-grade endotoxemia; direct effects of HIV and viral proteins on macrophage cholesterol metabolism; and dyslipidemia related to HIV infection and specific anti-retroviral therapies. Monocytes are the precursors of the lipid-laden foam cells within the atherosclerotic plaque and produce high levels of proinflammatory cytokines such as IL-6. The minor CD14+/CD16+ "proinflammatory" monocyte subpopulation is preferentially susceptible to HIV infection and may play a critical role in the pathogenesis of HIV-related CAD. In this review, the central role of monocytes/macrophages in HIV-related CAD and the importance of inflammation and cholesterol metabolism are discussed. J. Leukoc. Biol. 87: 589-598; 2010.
引用
收藏
页码：589 / 598
页数：10
相关论文
共 157 条
  • [51] The macrophage scavenger receptor at 30 years of age: current knowledge and future challenges
    Greaves, David R.
    Gordon, Siamon
    [J]. JOURNAL OF LIPID RESEARCH, 2009, 50 : S282 - S286
  • [52] Grunfeld C., 2009, AIDS
  • [53] Markers of inflammation and coronary artery calcification: A systematic review
    Hamirani, Yasmin S.
    Pandey, Shivda
    Rivera, Juan J.
    Ndumele, Chiadi
    Budoff, Matthew J.
    Blumenthal, Roger S.
    Nasir, Khurram
    [J]. ATHEROSCLEROSIS, 2008, 201 (01) : 1 - 7
  • [54] Harbord RM, 2009, NEW ENGL J MED, V360, P933, DOI 10.1056/NEJMc082413
  • [55] CD14++ CD16+ monocytes but not total monocyte numbers predict cardiovascular events in dialysis patients
    Heine, G. H.
    Ulrich, C.
    Seibert, E.
    Seiler, S.
    Marell, J.
    Reichart, B.
    Krause, M.
    Schlitt, A.
    Koehler, H.
    Girndt, M.
    [J]. KIDNEY INTERNATIONAL, 2008, 73 (05) : 622 - 629
  • [56] Role of viral replication, antiretroviral therapy, and immunodeficiency in HIV-associated atherosclerosis
    Hsue, Priscilla Y.
    Hunt, Peter W.
    Schnell, Amanda
    Kalapus, S. Craig
    Hoh, Rebecca
    Ganz, Peter
    Martin, Jeffrey N.
    Deeks, Steven G.
    [J]. AIDS, 2009, 23 (09) : 1059 - 1067
  • [57] Potential Role of Interleukin-18 in the Immunopathogenesis of AIDS: Involvement in Fratricidal Killing of NK Cells
    Iannello, Alexandre
    Samarani, Suzanne
    Debbeche, Olfa
    Ahmad, Rasheed
    Boulassel, Mohamed-Rachid
    Tremblay, Cecile
    Toma, Emil
    Routy, Jean-Pierre
    Ahmad, Ali
    [J]. JOURNAL OF VIROLOGY, 2009, 83 (12) : 5999 - 6010
  • [58] Normal CD16 expression and phagocytosis of Mycobacterium avium complex by monocytes from a current cohort of HIV-1-infected patients
    Jaworowski, A
    Ellery, P
    Maslin, CL
    Naim, E
    Heinlein, AC
    Ryan, CE
    Paukovics, G
    Hocking, J
    Sonza, S
    Crowe, SM
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2006, 193 (05) : 693 - 697
  • [59] CD16+ monocyte subset preferentially harbors HIV-1 and is expanded in pregnant malawian women with Plasmodium falciparum malaria and HIV-1 infection
    Jaworowski, Anthony
    Kamwendo, Deborah D.
    Ellery, Philip
    Sonza, Secondo
    Mwapasa, Victor
    Tadesse, Eyob
    Molyneux, Malcolm E.
    Rogerson, Stephen J.
    Meshnick, Steven R.
    Crowe, Suzanne M.
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2007, 196 (01) : 38 - 42
  • [60] Reciprocal regulation of inflammation and lipid metabolism by liver X receptors
    Joseph, SB
    Castrillo, A
    Laffitte, BA
    Mangelsdorf, DJ
    Tontonoz, P
    [J]. NATURE MEDICINE, 2003, 9 (02) : 213 - 219
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