The macrophage: the intersection between HIV infection and atherosclerosis

被引：109
作者：
Crowe, Suzanne M. [1 ,2 ,3 ]
Westhorpe, Clare L. V. [1 ]
Mukhamedova, Nigora [5 ]
Jaworowski, Anthony [1 ,3 ,4 ]
Sviridov, Dmitri [5 ]
Bukrinsky, Michael [6 ]
机构：
[1] Macfarlane Burnet Inst Med Res & Publ Hlth, Ctr Virol, Melbourne, Vic 3004, Australia
[2] Alfred Hosp, Infect Dis Unit, Melbourne, Vic, Australia
[3] Monash Univ, Dept Med, Melbourne, Vic 3004, Australia
[4] Monash Univ, Dept Immunol, Melbourne, Vic 3004, Australia
[5] Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia
[6] George Washington Univ, Med Ctr, Dept Microbiol Immunol & Trop Med, Washington, DC 20037 USA
来源：
JOURNAL OF LEUKOCYTE BIOLOGY | 2010年 / 87卷 / 04期
关键词：
inflammation; monocyte migration; cholesterol; coronary heart disease; C-REACTIVE PROTEIN; PERIPHERAL-BLOOD MONOCYTES; IMMUNODEFICIENCY-VIRUS TYPE-1; CORONARY-HEART-DISEASE; REVERSE-TRANSCRIPTASE INHIBITORS; ACTIVE ANTIRETROVIRAL THERAPY; PREFERENTIALLY HARBORS HIV-1; ACUTE MYOCARDIAL-INFARCTION; TOLL-LIKE RECEPTORS; FC-GAMMA RECEPTORS;
D O I：
10.1189/jlb.0809580
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
HIV-infected individuals are at increased risk of coronary artery disease (CAD) with underlying mechanisms including chronic immune activation and inflammation secondary to HIV-induced microbial translocation and low-grade endotoxemia; direct effects of HIV and viral proteins on macrophage cholesterol metabolism; and dyslipidemia related to HIV infection and specific anti-retroviral therapies. Monocytes are the precursors of the lipid-laden foam cells within the atherosclerotic plaque and produce high levels of proinflammatory cytokines such as IL-6. The minor CD14+/CD16+ "proinflammatory" monocyte subpopulation is preferentially susceptible to HIV infection and may play a critical role in the pathogenesis of HIV-related CAD. In this review, the central role of monocytes/macrophages in HIV-related CAD and the importance of inflammation and cholesterol metabolism are discussed. J. Leukoc. Biol. 87: 589-598; 2010.
引用
收藏
页码：589 / 598
页数：10
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